- Fomivirsen
width = 250
CAS_number=160369-77-7
ATC_prefix=S01
ATC_suffix=AD08
ATC_supplemental=
PubChem=
DrugBank=
C = 204 | H = 263 | N = 63 | O = 114 | P = 20 | S = 20
molecular_weight = 6682.4 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category = B2
legal_status =
routes_of_administration= Intravitreal injectionFomivirsen (brand name Vitravene) is an
antiviral drug . It is used in the treatment ofcytomegalovirus retinitis (CMV) inimmunocompromised patients, including those withAIDS .It is an
oligonucleotide that blocks translation of viral mRNA by binding to a coding segment of a key CMV gene. It was the firstantisense antiviral approved by the FDA. [Roush, W. 1997. Antisense aims for a renaissance. Science 276: 1192-93]It is 21 nucleotides in length and has the sequence: 5'-GCG TTT GCT CTT CTT CTT GCG-3'
It is available as an intraocular injection in a concentration of 6.6 mg/ml [Katzung, BG. Basic and Clinical Pharmacology 10th ed., 2007. McGraw-Hill Co., Inc.]
References
ee also
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retinitis External links
* [http://www.rxlist.com/cgi/generic2/fomivirsen.htm Diagram]
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