- Methylthiouracil
-
Methylthiouracil 
Systematic (IUPAC) name 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one Clinical data AHFS/Drugs.com International Drug Names Pregnancy cat. ? Legal status ? Identifiers CAS number 56-04-2 ATC code H03BA01 PubChem CID 667493 UNII QW24888U5F 
KEGG C19265 Chemical data Formula C5H6N2OS Mol. mass 142.18 g/mol 
(what is this?) (verify)Methylthiouracil is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.
Methylthiouracil is not used clinically in the United States, it has a similar mechanism of action and side effect to that of propylthiouricil.
The drug acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland.
The clinical effects of the drug to treat the hyperthyroid state can have a lag period of up to two weeks, depending on the stores of thyroglobulin and other factors.
Side effects
Like with any drug a wide variety of side effects can occur, but four topics should be kept in mind and the patient informed:
Agranulocytosis - develops rapidly, sore throat and fever are hallmark symptoms. Can be fatal if drug is not discontinued promptly.
Allergic skin reactions the most dangerous of which is Exfoliative Dermatitis, it rapidly can get out of control, notify the physician should a skin eruption occur.
Hepatitis - yellowing of the skin, nausea, yellowing of the whites of the eyes, flu-like symptoms.
Thrombocytopenia - unusual bruising or bleeding.
External links
see link on discussion of Hyperthyrodism: http://www.merck.com/mmpe/sec12/ch152/ch152e.html#S12_CH152_T002
Thyroid therapy (H03) Thyroid hormones Antithyroid preparations Thiouracils: Propylthiouracil# • Methylthiouracil • Benzylthiouracil
Sulfur-containing imidazole derivatives: Carbimazole • MethimazoleSodium-iodide symporter
inhibitorOther
This hormonal preparation article is a stub. You can help Wikipedia by expanding it.
