Benzylthiouracil

drugbox
IUPAC_name = 1-(1-cyclohexa-2,4-dienylmethyl)-7-thia-
3,5-diazabicyclo [4.1.0] hepta-3,5-dien-2-one

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CAS_number = 6336-50-1
ATC_prefix = H03
ATC_suffix = BA03
PubChem = 685814
DrugBank =
C=11|H=10|N=2|O=1|S=1
molecular_weight = 218.276 g/mol
bioavailability =
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excretion = Renal
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routes_of_administration = Oral

Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.

Adverse effects

Benzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage. [cite journal |author=Tieulie N, Huong DL, Andreu M, "et al" |title= [ANCA associated glomerulonephritis related to benzylthiouracil] |language=French |journal=Rev Med Interne |volume=23 |issue=10 |pages=853–6 |year=2002 |pmid=12428489 |doi=] [cite journal |author=Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H |title= [Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease] |language=French |journal=Rev Med Interne |volume=23 |issue=10 |pages=857–61 |year=2002 |pmid=12428490 |doi=] [cite journal |author=Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M |title= [Benzylthiouracil induced ANCA-positive vasculitis] |language=French |journal=Presse médicale |volume=33 |issue=19 Pt 1 |pages=1331–3 |year=2004 |pmid=15615240 |doi=] [cite journal |author=Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS |title=ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil |journal=Eur J Pediatr |volume=165 |issue=7 |pages=435–6 |year=2006 |pmid=16622664 |doi=10.1007/s00431-005-0053-4]

References