Cilazapril

Cilazapril
Cilazapril
IUPAC name
Cilazapril
Systematic name
9-[(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid[citation needed]
Identifiers
CAS number 88768-40-5 (1S,9S)-9-[(2S)-2-yl]amin,-1-carbox N
PubChem 2751, 40467985 (1R,9S)-9-[(2S)-2-yl]amin,-1-carbox, 56330 (1S,9S)-9-[(2S)-2-yl]amin,-1-carbox
ChemSpider 2649 N, 50831 YesY
UNII 8Q9454114Q N
DrugBank DB01340
KEGG D07699 YesY
ChEMBL CHEMBL515606 N
ATC code C09AA08
Jmol-3D images Image 1
Properties
Molecular formula C22H31N3O5
Molar mass 417.5 g mol−1
Exact mass 417.226371117 g mol-1
log P 2.212
Acidity (pKa) 2.285
Basicity (pKb) 11.712
Pharmacology
Routes of
administration		 Oral
Legal status

POM(UK)
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cilazapril is a pyridazine angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. It is branded as Inhibace in Canada, Zapril in New Zealand, Vascace and Dynorm in Europe. According to drugs.com (who have a partnership with the US Food & drug Administration) none of these are currently available in the United States as of May 2010.

Several stereo isomers exist of which, only one isomer is medically viable: cilazapril ((1S,9S)-9-[(2S)-2-yl]amin,-1-carbox)

References

Cilazapril monograph. Lexi-Comp Online, Lexi-Drugs Online, Lexi-Comp Inc. Hudson, OH. Available at: [1]. Accessed October 5th, 2008.

v · d · eAntihypertensives: agents acting on the renin-angiotensin system (C09)
ACE inhibitors
("-pril")
AIIRAs/
("-sartan")
Renin inhibitors/
("-kiren")
Aliskiren (+amlodipine) • Remikiren§

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)


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