Zofenopril

Drugbox
IUPAC_name = (2"S",4"S")-1- [(2"S")-3-(Benzoylsulfanyl)-2-methylpropanoyl] -4-phenylsulfanylpyrrolidine-2-carboxylic acid


CAS_number = 81872-10-8
CAS_supplemental =
ATC_prefix = C09
ATC_suffix = AA15
ATC_supplemental =
PubChem = 92400
DrugBank =
chemical_formula =
C=22 | H=23 | N=1 | O=4 | S=2
molecular_weight = 429.552 g/mol
bioavailability =
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routes_of_administration = Oral

Zofenopril (also known as Zofenoprilum [Latin] ) is an angiotensin converting enzyme (ACE) inhibitor with cardioprotective properties indicated for the treatment of hypertension. [cite journal |author=Ambrosioni E |title=Defining the role of zofenopril in the management of hypertension and ischemic heart disorders |journal=Am J Cardiovasc Drugs |volume=7 |issue=1 |pages=17–24 |year=2007 |pmid=17355163 |doi= |url=]

In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with less adverse effects. [cite journal |author=Nilsson P |title=Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension |journal=Blood Press Suppl |volume=2 |issue= |pages=25–30 |year=2007 |month=October |pmid=18046976 |doi= |url=] [cite journal |author=Mallion JM |title=An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension |journal=Blood Press Suppl |volume=2 |issue= |pages=13–8 |year=2007 |month=October |pmid=18046974 |doi= |url=]

References