Quinapril

drugbox
IUPAC_name = (3"S")-2- [(2"S")-2- [(1"S")-1-ethoxycarbonyl-3-phenyl-
propyl] amino] propanoyl] -3,4-dihydro-1"H"-isoquinoline-
3-carboxylic acid

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width = 180
CAS_number = 85441-61-8
ATC_prefix = C09
ATC_suffix = AA06
PubChem = 54892
DrugBank = APRD00523
C = 25 | H = 30 | N = 2 | O = 5
molecular_weight = 438.516 g/mol
bioavailability =
protein_bound = 97%
metabolism =
elimination_half-life = 2 hours
pregnancy_category = D
legal_status = Rx-only
routes_of_administration = Oral

Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure.

Pharmacology

Quinapril is a prodrug. It is converted to its active metabolite, quinaprilat, in the liver.

Mechanism of action

Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.

Indications

Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.

Contraindications

Pregnancy

Impaired renal and liver function

Patients with a history of angioedema related to previous treatment with an ACE inhibitor.

Hypersensitive to Quinapril

ide effects

Side effects of quinapril include dizziness, cough, vomiting, upset stomach, angioedema and fatigue.

External links

* [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a692026.html Quinapril FAQ]
* [http://www.accupril.com Accupril Site]