Galactitol

Galactitol
Galactitol
Identifiers
CAS number 608-66-2 YesY
PubChem 11850
ChemSpider 11357 YesY
ChEBI CHEBI:16813 YesY
Jmol-3D images Image 1
Properties
Molecular formula C6H14O6
Molar mass 182.17 g mol−1
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Galactitol (dulcitol) is a sugar alcohol, the reduction product of galactose.[1] In people with galactokinase deficiency, a form of galactosemia, excess dulcitol forms in the lens of the eye leading to cataracts.[2]

Galactitol is produced from galactose in a reaction catalyzed by aldose reductase. Galactose itself comes from the metabolism of the disaccharide lactose into glucose and galactose.

The other common galactose metabolism defect is a defect in galactose-1-phosphate uridylyltransferase, an autosomal recessive disorder, which also causes a buildup of galactitol as a result of increased concentrations of galactose-1-phosphate and galactose. The toxicity associated with galactose-1-phosphate uridylyltransferase deficiency is associated with symptoms of hepatosplenomegaly and mental retardation in addition to the cataracts caused by galactitol buildup.

References



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Look at other dictionaries:

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  • galactitol — A sugar alcohol derived from galactose; g. accumulates in transferase deficiency galactosemia. * * * ga·lac·ti·tol gə lak tə .tȯl n a white faintly sweet alcohol C6H14O6 that occurs in various plants esp. of the snapdragon family… …   Medical dictionary

  • Galactitol-1-phosphate 5-dehydrogenase — In enzymology, a galactitol 1 phosphate 5 dehydrogenase (EC number|1.1.1.251) is an enzyme that catalyzes the chemical reaction:galactitol 1 phosphate + NAD+ ightleftharpoons L tagatose 6 phosphate + NADH + H+Thus, the two substrates of this… …   Wikipedia

  • Galactitol 2-dehydrogenase — In enzymology, a galactitol 2 dehydrogenase (EC number|1.1.1.16) is an enzyme that catalyzes the chemical reaction:galactitol + NAD+ ightleftharpoons D tagatose + NADH + H+Thus, the two substrates of this enzyme are galactitol and NAD+, whereas… …   Wikipedia

  • galactitol — noun iditol <! or an isomer? …   Wiktionary

  • 1-Déoxy-D-galactitol — Fucitol Fucitol Général Nom IUPAC 2R,3S,4R,5S) hexane 1,2,3,4,5 pentol Synonymes …   Wikipédia en Français

  • 6-Déoxy-L-galactitol — Fucitol Fucitol Général Nom IUPAC 2R,3S,4R,5S) hexane 1,2,3,4,5 pentol Synonymes …   Wikipédia en Français

  • dulcite, dulcitol, dulcose — Galactitol …   Medical dictionary

  • Galactosemic cataract — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD9 = ICD9|366.44, ICD9|271.1 ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = A Galactosemic cataract is cataract which is associated with the consequences of… …   Wikipedia

  • Galactosemia — Classification and external resources Galactose ICD 10 E …   Wikipedia

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