Galactitol(2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexolOther namesD-Galactitol; Dulcitol Identifiers CAS number 608-66-2 PubChem 11850 ChemSpider 11357 ChEBI CHEBI:16813 Jmol-3D images Image 1
Properties Molecular formula C6H14O6 Molar mass 182.17 g mol−1 (verify) (what is: /?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Galactitol (dulcitol) is a sugar alcohol, the reduction product of galactose. In people with galactokinase deficiency, a form of galactosemia, excess dulcitol forms in the lens of the eye leading to cataracts.
Galactitol is produced from galactose in a reaction catalyzed by aldose reductase. Galactose itself comes from the metabolism of the disaccharide lactose into glucose and galactose.
The other common galactose metabolism defect is a defect in galactose-1-phosphate uridylyltransferase, an autosomal recessive disorder, which also causes a buildup of galactitol as a result of increased concentrations of galactose-1-phosphate and galactose. The toxicity associated with galactose-1-phosphate uridylyltransferase deficiency is associated with symptoms of hepatosplenomegaly and mental retardation in addition to the cataracts caused by galactitol buildup.
- ^ "Galactitol - Compound Summary". National Center for Biotechnology Information. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11850. Retrieved 2008-08-06.
- ^ Roth, KS (September 10, 2007). "Galactokinase Deficiency". eMedicine. WebMD. http://www.emedicine.com/ped/TOPIC815.HTM. Retrieved 2008-08-08.
FructoseFructose-1-phosphate → DHAP/Glyceraldehyde → Glyceraldehyde 3-phosphate Galactose
Galactose-1-phosphate → Glucose 1-phosphate → Glucose 6-phosphate → Fructose 6-phosphate
Uridine diphosphate galactose · Uridine diphosphate glucoseGalactitol · Iditol
- Sugar alcohols
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