Debrisoquine

Debrisoquine: Debrisoquine^[1]

IUPAC name

1,2,3,4-tetrahydroisoquinoline-2-carboximidamide

Identifiers

CAS number 1131-64-2^Y

PubChem 2966

ChemSpider 2860^Y

UNII X31CDK040E^Y

DrugBank DB04840

KEGG C13650^Y

MeSH Debrisoquine

ChEBI CHEBI:34665^Y

ChEMBL CHEMBL169901^Y

Jmol-3D images Image 1

SMILES

[N@H]=C(N)N2Cc1c(cccc1)CC2

InChI

InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)^Y
Key: JWPGJSVJDAJRLW-UHFFFAOYSA-N^Y
InChI=1/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
Key: JWPGJSVJDAJRLW-UHFFFAOYAE

Properties

Molecular formula C₁₀H₁₃N₃

Molar mass 175.23032

Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a drug metabolizing enzyme.^[2]

See also

Isoquinoline#Applications of derivatives

References

^ Debrisoquine - Compound Summary, PubChem.

^ [1] Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the "Cocktail" Approach

v · d · eSympatholytic (and closely related) antihypertensives (C02)

Sympatholytics
(antagonize α-adrenergic
vasoconstriction)

Central

α₂ agonist

Clonidine • Guanfacine • Methyldopa #

Adrenergic release inhibitors

Bethanidine • Bretylium • Debrisoquine • Guanadrel • Guanazodine • Guanethidine • Guanoclor • Guanoxan • Guanazodine • Guanoxabenz • Guanoxan

Imidazoline receptor agonist

Moxonidine • Rilmenidine

Ganglion-blocking/nicotinic antagonist

Mecamylamine • Pentolinium • Trimethaphan

Peripheral

Indirect

MAOI

Pargyline

Adrenergic uptake inhibitor

Rescinnamine • Reserpine

Tyrosine hydroxylase inhibitor

Metirosine

Direct

α₁ blockers

Prazosin • Indoramin • Trimazosin • Doxazosin • Urapidil

Non-selective α blocker

Phentolamine

Other antagonists

Serotonin antagonist

Ketanserin

Endothelin antagonist (for PH)

dual (Bosentan) • selective (Ambrisentan, Sitaxentan)

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)

Categories:
Guanidines
Tetrahydroisoquinolines
Antihypertensive agents
Antihypertensive agent stubs

Debrisoquine^[1]

IUPAC name 1,2,3,4-tetrahydroisoquinoline-2-carboximidamide
Identifiers
CAS number	1131-64-2^Y
PubChem	2966
ChemSpider	2860^Y
UNII	X31CDK040E^Y
DrugBank	DB04840
KEGG	C13650^Y
MeSH	Debrisoquine
ChEBI	CHEBI:34665^Y
ChEMBL	CHEMBL169901^Y
Jmol-3D images	Image 1
SMILES [N@H]=C(N)N2Cc1c(cccc1)CC2
InChI InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)^Y Key: JWPGJSVJDAJRLW-UHFFFAOYSA-N^Y InChI=1/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12) Key: JWPGJSVJDAJRLW-UHFFFAOYAE
Properties
Molecular formula	C₁₀H₁₃N₃
Molar mass	175.23032
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

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Look at other dictionaries:

debrisoquine — noun A drug (derived from isoquinoline) used in the treatment of hypertension … Wiktionary
debrisoquine — n. a potent drug used to treat high blood pressure (hypertension). It is administered by mouth; common side effects are nausea, headache, sweating, and general malaise. * * * deb·ris·o·quine (deb risґo kwin) INN and BAN for debrisoquin … Medical dictionary
debrisoquine sulfate — An antihypertensive agent resembling guanethidine; also used in drug metabolism studies … Medical dictionary
Дебризохин (Debrisoquine) — сильнодействующее лекарственное вещество, применяемое для лечения повышенного кровяного давления (гипертензии). Назначается внутрь; возможные побочные эффекты: тошнота, головная боль, повышенная потливость и общее недомогание. Торговое название:… … Медицинские термины
ДЕБРИЗОХИН — (debrisoquine) сильнодействующее лекарственное вещество, применяемое для лечения повышенного кровяного давления (гипертензии). Назначается внутрь; возможные побочные эффекты: тошнота, головная боль, повышенная потливость и общее недомогание.… … Толковый словарь по медицине
Michel Eichelbaum — (* 19. Mai 1941 in Leipzig) ist ein deutscher Internist und Klinischer Pharmakologe. Er ist besonders bekannt durch seine Arbeiten über den Einfluss von Genmutationen auf die Pharmakokinetik von Arzneistoffen … Deutsch Wikipedia
CYP2D6 — Cytochrome P450, family 2, subfamily D, polypeptide 6 PDB rendering based on 2f9q … Wikipedia
DÉTOXICATION — Le terme détoxication recouvre l’ensemble des biotransformations que subissent certains composés exogènes (médicaments par exemple) ou endogènes (hormones stéroïdes, bilirubine) en vue de leur élimination de l’organisme. Ces composés possèdent un … Encyclopédie Universelle
Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… … Wikipedia
Beta blocker — Beta blockers Drug class Skeletal formula of propranolol, the first clinically successful beta blocker ATC code C07 … Wikipedia

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Debrisoquine

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