Dryvax

Dryvax is a freeze-dried calf lymph smallpox vaccine. It is the world's oldest smallpox vaccine, created in the late 19th century by American Home Products, a predecessor of Wyeth. By the 1940s, Wyeth was the leading US manufacturer of the vaccine and the only manufacturer by the 1960s. After world health authorities declared smallpox had been eradicated from nature in 1980, Wyeth stopped making the vaccine.^[1]

The smallpox vaccine diluent in a syringe along side a vial of Dryvax® dried smallpox vaccine.

The US Centers for Disease Control and Prevention (CDC) kept a stockpile of the drug to use in case of emergency. In 2003 this supply helped contain an outbreak of monkeypox in the United States. In February 2008 the CDC disposed of the last of its 12 million doses of Dryvax. Its supply is being replaced by ACAM2000, a more modern product manufactured in laboratories by Acambis, now a division of Sanofi Pasteur.^[1][2]

Dryvax is a live-virus preparation of vaccinia prepared from calf lymph. Trace amounts of the following antibiotics (added during processing) may be present: neomycin sulfate, chlortetracycline hydrochloride, polymyxin B sulfate, and dihydrostreptomycin sulfate.^[3]

The vaccine is effective, providing successful immunogenicity in about 95% of vaccinated persons. Dryvax has serious adverse side-effects in about 1% to 2% of cases.^[4]

References

1. ^ ^{a b} "CDC to Destroy Oldest Smallpox Vaccine". http://hosted.ap.org/dynamic/stories/S/SMALLPOX_VACCINE?SITE=NMALJ&SECTION=HOME&TEMPLATE=DEFAULT&CTIME=2008-02-29-18-22-12. Retrieved 2008-03-02. ^{[dead link]}
2. ^ Safety Surveillance Study of ACAM2000® Vaccinia Vaccine - Full Text View - ClinicalTrials.gov
3. ^ Wyeth package insert / U.S. Food and Drug administration
4. ^ Metzger W, Mordmueller BG (2007). "Vaccines for preventing smallpox". Cochrane Database Syst Rev (3): CD004913. doi:10.1002/14651858.CD004913.pub2. PMID 17636779. 

This vaccine article is a stub. You can help Wikipedia by expanding it.v · Categories: Vaccines Vaccine stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Only Love Strangers James Stanley Speakman Look at other dictionaries: ACAM2000 — is a smallpox vaccine developed by [http://www.acambis.com/ Acambis] . It was approved for use in the United States in 2007. It contains live vaccinia virus, cloned from the same strain used in an earlier vaccine, DryVax. While the DryVax virus… …   Wikipedia Vaccination — Intervention Child receiving an oral polio vaccine ICD 9 CM …   Wikipedia Vaccine — For other uses, see Vaccine (disambiguation). A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease causing microorganism, and is often made from… …   Wikipedia DNA vaccination — The making of a DNA vaccine. DNA vaccination is a technique for protecting an organism against disease by injecting it with genetically engineered DNA to produce an immunological response. Nucleic acid vaccines are still experimental, and have… …   Wikipedia MMR vaccine — Combination of Measles vaccine Vaccine Mumps vaccine Vaccine Rubella vaccine Vaccine Clinical data Pregnancy cat.  ? …   Wikipedia Thiomersal — Thiomersal …   Wikipedia Vaccinia — Taxobox | color=violet name = Vaccinia virus image caption = A TEM micrograph of Vaccinia virus virions. virus group = i familia = Poxviridae genus = Orthopoxvirus species = Vaccinia virus DiseaseDisorder infobox Name = Vaccinia ICD10 = B08.0… …   Wikipedia DPT vaccine — For other uses, see DTP (disambiguation). DPT vaccine Combination of Diphtheria vaccine Vaccine Pertussis vaccine Vaccine Tetanus vaccine Vaccine Clinical data Pregnancy cat.  ? …   Wikipedia Postherpetic neuralgia — PHN redirects here. For the Spanish National Water Plan (Plan Hidrológico Nacional), see Water supply and sanitation in Spain. Postherpetic neuralgia Classification and external resources ICD 10 B02.2, G53.0, G44.847 ICD 9 …   Wikipedia FluMist — Influenza (Flu) …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”