- Motavizumab
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Motavizumab ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target RSV glycoprotein F Clinical data Pregnancy cat. ? Legal status ? Routes i.v. Pharmacokinetic data Protein binding non Identifiers CAS number 677010-34-3 ATC code None UNII 50Y163LK8Q KEGG D06621 Chemical data Formula C6476H10014N1706O2008S48 Mol. mass Approximately 148 kDa (what is this?) (verify) Motavizumab (proposed INN, trade name Numax) is a humanized monoclonal antibody. It is being investigated by MedImmune (today a subsidiary of AstraZeneca) for the prevention of respiratory syncytial virus infection in high-risk infants. As of September 2009[update], it is undergoing Phase II and III clinical trials.[1]
In December 2010, AstraZeneca in a stock market statement stated that it would be writing down $445m (£286m) after discontinuing a key development programme for Motavizumab. The company stated that it would no longer develop Motavizumab for the prevention of respiratory syncytial virus (RSV), and as a result was withdrawing its licence application to the US Food and Drug Administration. It added that it would continue to develop Motavizumab for other treatments of RSV.[2]
References
- ^ ClinicalTrials.gov
- ^ "AstraZeneca halts work on Motavizumab drug". BBC News. 21 December, 2010. http://www.bbc.co.uk/news/business-12047666. Retrieved 2010-12-21.
External links
Monoclonal antibodies for infectious disease and toxins Fungal ("-fung-") Human ("-fungu-")Viral ("-vi(r)-") Human ("-viru-")Humanized ("-vizu-")Felvizumab • Motavizumab • Palivizumab • SuvizumabBacterial ("-ba(c)-") Human ("-bacu-")Nebacumab • Panobacumab • RaxibacumabMouse ("-baco-")Chimeric ("-baxi-")Humanized ("-bazu-")Toxin ("-tox(a)-") Humanized ("-toxazu-")AstraZeneca Products Anastrozole · Atenolol · Brompheniramine · Budesonide · Disufenton sodium · Esomeprazole · FluMist · Gefitinib · Goserelin · Isosorbide mononitrate · Motavizumab · Omeprazole · Palivizumab · Propofol · Rosuvastatin · Tamoxifen · Ticagrelor · Vandetanib · Ximelagatran · ZolmitriptanPredecessors and
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