Efungumab ?
Monoclonal antibody
Type Single-chain variable fragment
Source Human
Target fungal Hsp90
Clinical data
Pregnancy cat.  ?
Legal status  ?
Routes Intravenous
Pharmacokinetic data
Bioavailability Not applicable (IV only)
Protein binding High
Half-life 1–2 hours
ATC code None
Chemical data
Formula  ?
Mol. mass Approximately 27.2 kDa
 N(what is this?)  (verify)

Efungumab (trade name Mycograb) is a drug developed by NeuTec Pharma (a subsidiary of Novartis), intended to treat invasive Candida infection in combination with amphotericin B. The European Medicines Agency has twice refused to grant marketing authorization for Mycograb, citing product safety and quality issues.[1]

Chemically, efungumab is a single-chain variable fragment of a human monoclonal antibody.[2] As such, it potentially act similarly to an IgA - inhibiting by binding and blocking.


  1. ^ European Medicines Agency (2007). REFUSAL CHMP ASSESSMENT REPORT FOR MYCOGRAB. Procedure No. EMEA/H/C/658PDF (370 KiB). London: European Medicines Agency. Retrieved on 2007-11-20. Detailed assessment report with comprehensive overview of reasons for refusal of marketing authorization.
  2. ^ World Health Organization (2006). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 95" (PDF). WHO Drug Information 20 (2): 48. http://whqlibdoc.who.int/druginfo/20_2_2006_INN95.pdf.