Nicorandil Systematic (IUPAC) name 2-[(pyridin-3-ylcarbonyl)amino]ethyl nitrate Clinical data AHFS/Drugs.com International Drug Names Pregnancy cat. B3(AU) Legal status POM (UK) Routes Oral Pharmacokinetic data Bioavailability 75 to 80% Protein binding 25% Metabolism Hepatic Half-life 1 hour Excretion Renal (21%) Identifiers CAS number 65141-46-0 ATC code C01DX16 PubChem CID 47528 IUPHAR ligand 2411 ChemSpider 43240 UNII 260456HAM0 KEGG D01810 ChEMBL CHEMBL284906 Chemical data Formula C8H9N3O4 Mol. mass 211.175 g/mol SMILES eMolecules & PubChem (what is this?) (verify)
Nicorandil is a vasodilatory drug used to treat angina. It is marketed under the trade names Ikorel (in the United Kingdom, Australia and most of Europe), Dancor (in Switzerland), Nikoran (in India), Aprior (in the Philippines), Nitorubin (in Japan) and Sigmart (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States.
It works by opening KATP potassium channels.
Common side effects include flushing, palpitation, weakness, headache, mouth ulcers, nausea and vomiting. More recently peri-anal, ileal and peri-stomal ulceration has been reported as a side effect. Anal ulceration is now included in the British National Formulary as a reported side effect.
Can also give the feeling of severe toothache, and nasal congestion
Mechanism of Action
Activates the K channel, therefore there is an increased K permeability. this leads to vascular smooth muscle hyperpolarisation causing the closure of Ca L-type channel, thus reduced intracellular free Ca, thus vasodialation.
- Kukovetz WR, Holzmann S, Pöch G (1992). "Molecular mechanism of action of nicorandil". J. Cardiovasc. Pharmacol. 20 (Suppl 3): S1–7. PMID 1282168.
- Tripathi, K.D. Essentials of Medical Pharmacology, chapter 37, page 499.
- Dr.Hosny Mohaed, Brief ACSs.
Vasodilators used in cardiac diseases (C01D) Nitrates/nitrovasodilatorsGlyceryl trinitrate # • Isosorbide dinitrate # • Isosorbide mononitrate • Linsidomine • Molsidomine • Pentaerythritol tetranitrate Quinolone vasodilators OthersItramin tosilate • Prenylamine • Oxyfedrine • Benziodarone • Carbocromen • Hexobendine • Etafenone • Heptaminol • Imolamine • Dilazep • Trapidil • Molsidomine • Efloxate • Cinepazet • Cloridarol • Nicorandil • Nesiritide • Gapicomine • Pimobendan#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase IIICategories:
- Alkyl nitrates
- Potassium channel openers
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