Systematic (IUPAC) name
2-[(pyridin-3-ylcarbonyl)amino]ethyl nitrate
Clinical data
AHFS/ International Drug Names
Pregnancy cat. B3(AU)
Legal status POM (UK)
Routes Oral
Pharmacokinetic data
Bioavailability 75 to 80%
Protein binding 25%
Metabolism Hepatic
Half-life 1 hour
Excretion Renal (21%)
CAS number 65141-46-0
ATC code C01DX16
PubChem CID 47528
IUPHAR ligand 2411
ChemSpider 43240 YesY
UNII 260456HAM0 YesY
KEGG D01810 YesY
Chemical data
Formula C8H9N3O4 
Mol. mass 211.175 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Nicorandil is a vasodilatory drug used to treat angina. It is marketed under the trade names Ikorel (in the United Kingdom, Australia and most of Europe), Dancor (in Switzerland), Nikoran (in India), Aprior (in the Philippines), Nitorubin (in Japan) and Sigmart (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States.

It works by opening KATP potassium channels.

Side effects

Common side effects include flushing, palpitation, weakness, headache, mouth ulcers, nausea and vomiting. More recently peri-anal, ileal and peri-stomal ulceration has been reported as a side effect. Anal ulceration is now included in the British National Formulary as a reported side effect.

Can also give the feeling of severe toothache, and nasal congestion

Mechanism of Action

Activates the K channel, therefore there is an increased K permeability. this leads to vascular smooth muscle hyperpolarisation causing the closure of Ca L-type channel, thus reduced intracellular free Ca, thus vasodialation.


  • Kukovetz WR, Holzmann S, Pöch G (1992). "Molecular mechanism of action of nicorandil". J. Cardiovasc. Pharmacol. 20 (Suppl 3): S1–7. PMID 1282168. 
  • Tripathi, K.D. Essentials of Medical Pharmacology, chapter 37, page 499.
  • Dr.Hosny Mohaed, Brief ACSs.

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