- Molsidomine
-
Molsidomine 
1-Ethoxy-N-(3-morpholino-5-oxadiazol-3-iumyl)methanimidateIdentifiers CAS number 25717-80-0 PubChem 5353788 ChemSpider 4090 
KEGG D01320 Jmol-3D images Image 1 - [O-]C(OCC)=Nc2on[n+](N1CCOCC1)c2
- InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3
Key: XLFWDASMENKTKL-UHFFFAOYSA-N
InChI=1/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3
Key: XLFWDASMENKTKL-UHFFFAOYAC
Properties Molecular formula C9H14N4O4 Molar mass 242.23 g/mol 
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)Infobox references Molsidomine is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite SIN-1. SIN-1 is an unstable compound that releases nitric oxide upon decay as the actual vasodilating compound.
Chemical structure of SIN-1
Chemistry
Molsidomine as well as SIN-1 are sydnone imines, a class of mesoionic heterocyclic aromatic chemical compounds.
See also
- Nitric oxide
- Nitric oxide releaser
- Vasodilator
Vasodilators used in cardiac diseases (C01D) Nitrates/nitrovasodilators Glyceryl trinitrate # • Isosorbide dinitrate # • Isosorbide mononitrate • Linsidomine • Molsidomine • Pentaerythritol tetranitrateQuinolone vasodilators Others Itramin tosilate • Prenylamine • Oxyfedrine • Benziodarone • Carbocromen • Hexobendine • Etafenone • Heptaminol • Imolamine • Dilazep • Trapidil • Molsidomine • Efloxate • Cinepazet • Cloridarol • Nicorandil • Nesiritide • Gapicomine • Pimobendan#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III 
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