Gapicomine

Drugbox
IUPAC_name = 1-Pyridin-4-yl-"N"-(pyridin-4-ylmethyl)methanamine

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CAS_number = 1539-39-5
ATC_prefix =
ATC_suffix =
PubChem = 68955
DrugBank =
C=12|H=13|N=3
molecular_weight = 199.25 g/mol
bioavailability =
protein_bound =
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pregnancy_AU =
pregnancy_US =
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legal_status = off market (was used in EU countries)
routes_of_administration = oral (tablet)

Gapicomine (INN) is a coronary vasodilator. It has been withdrawn from the market in the countries it was used in. [cite web |url=http://www.justscience.de/en/drugbase/indexnominum/monograph.html?tx_crondavindexnominum_pi%5Bmonograph_uid%5D=3597&cHash=e51fae0af1 |title=Gapicomine Monograph, The Index Nominum |accessdate=2008-03-31 |format= |work=]

Also, gapicomine is a major component in the drug bicordin. [cite web |url=http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=211061 |title=Bicordin, PubChem |accessdate=2008-03-31 |format= |work=]

History

Gapicomine was discovered in 1970 by Polish chemist Stanisław Biniecki. It was first published about in an article of "The Polish Journal of Medicine and Pharmacy" describing the derivative drug bicordin in 1974.cite journal |author=Samochowiec L, Wójcicki J, Gregorczyk K, Szmatloch E. |title=Bicordin--a new drug in the treatment of coronary heart disease. |journal=Mater Med Pol. |volume= |issue= |pages=298–300 |year=1974 |pmid=4453155 |doi=]

References