Oxybuprocaine

Oxybuprocaine

Systematic (IUPAC) name
2-diethylaminoethyl 4-amino-3-butoxy-benzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	D(AU)
Legal status	?
Identifiers
CAS number	99-43-4 Y
ATC code	D04AB03 S01HA02
PubChem	CID 4633
DrugBank	APRD00817
ChemSpider	4472 Y
UNII	AXQ0JYM303 Y
KEGG	D08319 Y
ChEBI	CHEBI:309594 N
ChEMBL	CHEMBL1200 Y
Chemical data
Formula	C17H29ClN2O3
Mol. mass	344.877 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C17H28N2O3/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3/h8-9,13H,4-7,10-12,18H2,1-3H3 Y Key:CMHHMUWAYWTMGS-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Oxybuprocaine (INN), also known as benoxinate or BNX, is the name of a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine is sold by Novartis under the brand names Novesine or Novesin.

Safety for use in pregnancy and lactation has not been established.

Surgical use

• In ophthalmology in order to numb the surface of the eye (the outermost layers of the cornea and conjunctiva) for the following purposes:
  • In order to perform a contact/applanation tonometry.
  • In order to remove small foreign objects from the uppermost layer of the cornea or conjunctiva.
• In otolaryngology for numbing the mucous membranes of the nostrils.

Adverse effects

Oxybuprocaine like any other topical anesthetic used in the eye (like for example tetracaine, proxymetacaine and proparacaine) can cause irreversible corneal damage and even complete destruction of the cornea when used excessively (excessive use means several times a day during several days or even weeks).

See also

• Topical anesthetic