Pegfilgrastim

Pegfilgrastim
Pegfilgrastim
Systematic (IUPAC) name
N-(3-Hydroxypropyl)Methionylcolony-stimulating Factor (human), 1-Ether with .Alpha.-Methyl-.Omega.-Hydroxypoly(Oxyethylene)
Clinical data
Trade names Neulasta
AHFS/Drugs.com monograph
MedlinePlus a607058
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Half-life 15-80 hrs
Identifiers
CAS number 208265-92-3 YesY
ATC code L03AA13
DrugBank BTD00094
UNII 3A58010674 N
KEGG D06889 YesY
ChEMBL CHEMBL1201568 N
Chemical data
Formula C845H1343N223O243S9 + PEG 
Mol. mass 39000 g/mol
 N(what is this?)  (verify)

Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog, filgrastim. Like GCSF, the pegylated form serves to stimulate the level of white blood cells (neutrophils).[1]

Amgen manufactures pegfilgrastim under the brand name Neulasta, and Roche under the name Neulastim. The drug is prepared by coupling a 20 kDa Polyethylene glycol (PEG) molecule to the N-terminus of the filgrastim protein. Pegfilgrastim has a human half-life of 15 to 80 hours, much longer than the parent filgrastim (3–4 hours).[2]

Pegfilgrastim treatment can be used to stimulate the bone marrow to produce more neutrophils to fight infection in patients undergoing chemotherapy. Pegfilgrastim can be given on the first day of chemotherapy. As it supports white blood cell production, using this medicine prophylactically can allow an increased dose intensity of chemotherapy agents. Chemotherapy cycles can be repeated with greater frequency (increased dose-density), diminishing tumor regrowth.[3]

External links

v · d · eImmunomodulators: Immunostimulants (L03)
Endogenous

alpha: Interferon alpha natural • Interferon alfa-2a/Peginterferon alfa-2a • Interferon alfa-2b/Peginterferon alfa-2b • Interferon alfa-n1 • Interferon alfacon-1

beta: Interferon beta natural • Interferon beta-1a • Interferon beta-1b

Interferon gamma
Other protein/peptide
Pegademase • Immunocyanin • Tasonermin • Prolactin • Growth hormone
Other
Female sex steroids • Vitamin D • Poly ICLC • Histamine dihydrochloride
Exogenous
vaccine (BCG vaccine, Melanoma vaccine) • beta-glucan (Lentinan) • Mifamurtide • thiazolidine (Pidotimod) • heterocyclic compound (Plerixafor) • polyribonucleotide (Polyinosinic:polycytidylic acid) • hydroxyquinoline (Roquinimex) • oligopeptide (Glatiramer acetate, Thymopentin)

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)

References

  1. ^ Walsh, G, Spada, S. "Epogen/Procrit" in: Directory of approved biopharmaceutical products. CRC Press, 2005, pp. 136-137.
  2. ^ Ho, R.J.Y., Gibaldi, M. Biotechnology and biopharmaceuticals: transforming proteins and genes into drugs Wiley-IEEE, 2003, p. 139, 158.
  3. ^ Polovich, M., Whitford, J.M., & Olsen, M. [Eds](2010). Chemotherapy and biotherapy guidelines and recommendations for practice (3rd. ed.). Pittsburgh, PA: Oncology Nursing Society.


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