Ancestim

Drugbox
IUPAC_name =


CAS_number =
ATC_prefix = L03
ATC_suffix = AA12
PubChem =
DrugBank =
chemical_formula =
molecular_weight =
bioavailability =
protein_bound =
metabolism =
elimination_half-life = 2.5 h
excretion = renal: 90%
clearance = 35-40 mL/kg/h
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_GER = not available
legal_status =
routes_of_administration = s.c. injection only, premedication with H1 and H2 antihistamines and beta-receptor agonists for bronchodilationAncestim is a recombinant methionyl human stem cell factor, commonly known by the name StemGen.

It is a 166 amino acid protein produced by Ecoli bacteria into which a gene has been inserted for soluble human stem cell factor.cite journal |author=da Silva MG, Pimentel P, Carvalhais A, "et al" |title=Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection |journal=Bone Marrow Transplant. |volume=34 |issue=8 |pages=683–91 |year=2004 |pmid=15322567 |doi=10.1038/sj.bmt.1704602] It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine retained after expression in Ecoli. Because Ancestim is produced in Ecoli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised powder for reconstitution and administration as a subcutaneous (SC) injection.

References