Far upstream element-binding protein 1

Far upstream element-binding protein 1
Far upstream element (FUSE) binding protein 1

PDB rendering based on 1j4w.
Identifiers
Symbols FUBP1; FBP; FUBP
External IDs OMIM603444 MGI1196294 HomoloGene48253 GeneCards: FUBP1 Gene
RNA expression pattern
PBB GE FUBP1 203091 at tn.png
PBB GE FUBP1 214093 s at tn.png
PBB GE FUBP1 214094 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8880 51886
Ensembl ENSG00000162613 ENSMUSG00000028034
UniProt Q96AE4 Q0P6B2
RefSeq (mRNA) NM_003902 NM_057172.3
RefSeq (protein) NP_003893 NP_476513.2
Location (UCSC) Chr 1:
78.41 – 78.44 Mb
Chr 3:
151.87 – 151.9 Mb
PubMed search [1] [2]

Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.[1][2]

This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.[2]

Interactions

Far upstream element-binding protein 1 has been shown to interact with MAPK14[3] and SMN1.[4]

References

  1. ^ Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (Apr 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259. 
  2. ^ a b "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8880. 
  3. ^ Kim, Min Jung; Park Bum-Joon, Kang Young-Sun, Kim Hyoung June, Park Jae-Hyun, Kang Jung Woo, Lee Sang Won, Han Jung Min, Lee Han-Woong, Kim Sunghoon (Jul. 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. (United States) 34 (3): 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782. 
  4. ^ Williams, B Y; Hamilton S L, Sarkar H K (Mar. 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. (NETHERLANDS) 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235. 

Further reading


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