PUF60

Fuse-binding protein-interacting repressor, also known as SIAHBP1, is a human gene.cite web | title = Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22827| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.cite web | title = Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22827| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Page-McCaw PS, Amonlirdviman K, Sharp PA |title=PUF60: a novel U2AF65-related splicing activity. |journal=RNA |volume=5 |issue= 12 |pages= 1548–60 |year= 2000 |pmid= 10606266 |doi=
*cite journal | author=Bouffard P, Barbar E, Brière F, Boire G |title=Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. |journal=RNA |volume=6 |issue= 1 |pages= 66–78 |year= 2000 |pmid= 10668799 |doi=
*cite journal | author=Poleev A, Hartmann A, Stamm S |title=A trans-acting factor, isolated by the three-hybrid system, that influences alternative splicing of the amyloid precursor protein minigene. |journal=Eur. J. Biochem. |volume=267 |issue= 13 |pages= 4002–10 |year= 2000 |pmid= 10866799 |doi=
*cite journal | author=Liu J, He L, Collins I, "et al." |title=The FBP interacting repressor targets TFIIH to inhibit activated transcription. |journal=Mol. Cell |volume=5 |issue= 2 |pages= 331–41 |year= 2000 |pmid= 10882074 |doi=
*cite journal | author=Liu J, Akoulitchev S, Weber A, "et al." |title=Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum. |journal=Cell |volume=104 |issue= 3 |pages= 353–63 |year= 2001 |pmid= 11239393 |doi=
*cite journal | author=Sandrock B, Egly JM |title=A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35328–33 |year= 2001 |pmid= 11445587 |doi= 10.1074/jbc.M105570200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Liu J, Kouzine F, Nie Z, "et al." |title=The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression. |journal=EMBO J. |volume=25 |issue= 10 |pages= 2119–30 |year= 2006 |pmid= 16628215 |doi= 10.1038/sj.emboj.7601101
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Hastings ML, Allemand E, Duelli DM, "et al." |title=Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF65. |journal=PLoS ONE |volume=2 |issue= 6 |pages= e538 |year= 2007 |pmid= 17579712 |doi= 10.1371/journal.pone.0000538

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