PARC (gene)

Cullin 9
Identifiers
Symbols	CUL9; DKFZp686G1042; DKFZp686P2024; H7AP1; PARC; RP3-330M21.2
External IDs	OMIM: 607489 MGI: 1925559 HomoloGene: 56696 GeneCards: CUL9 Gene
Gene Ontology Molecular function • nucleotide binding • protein binding • ATP binding • zinc ion binding • ubiquitin protein ligase binding • metal ion binding Cellular component • cytoplasm • cullin-RING ubiquitin ligase complex Biological process • ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23113	78309
Ensembl	ENSG00000112659	ENSMUSG00000040327
UniProt	Q8IWT3	Q80TT8
RefSeq (mRNA)	NM_015089	NM_001081335.1
RefSeq (protein)	NP_055904	NP_001074804.1
Location (UCSC)	Chr 6: 43.15 – 43.19 Mb	Chr 17: 46.64 – 46.68 Mb
PubMed search	[1]	[2]

Cullin-9 is a protein that in humans is encoded by the CUL9 gene.^[1][2][3][4]

Interactions

PARC (gene) has been shown to interact with P53.^[3]

References

1. ^ Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA (Mar 2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328. 
2. ^ Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (Nov 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492. 
3. ^ ^{a b} Nikolaev AY, Li M, Puskas N, Qin J, Gu W (Jan 2003). "Parc: a cytoplasmic anchor for p53". Cell 112 (1): 29–40. doi:10.1016/S0092-8674(02)01255-2. PMID 12526791. 
4. ^ "Entrez Gene: PARC p53-associated parkin-like cytoplasmic protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23113. 

Further reading

• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Issaeva N, Bozko P, Enge M, et al. (2005). "Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors". Nat. Med. 10 (12): 1321–8. doi:10.1038/nm1146. PMID 15558054. 
• Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi:10.1074/jbc.C600041200. PMID 16672220. 
• Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.