WASL (gene)

WASL (gene)
Wiskott-Aldrich syndrome-like

Rendering of WASL from PDB 2FF3
Identifiers
Symbols WASL; DKFZp779G0847; MGC48327; N-WASP; NWASP
External IDs OMIM605056 MGI1920428 HomoloGene74515 GeneCards: WASL Gene
RNA expression pattern
PBB GE WASL 205810 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8976 73178
Ensembl ENSG00000106299 ENSMUSG00000029684
UniProt O00401 Q05CX6
RefSeq (mRNA) NM_003941 NM_028459
RefSeq (protein) NP_003932 NP_082735
Location (UCSC) Chr 7:
123.32 – 123.39 Mb
Chr 6:
24.56 – 24.61 Mb
PubMed search [1] [2]

Neural Wiskott-Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene.[1][2][3]

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.[3]

According to one study, mouse DAB1 regulates actin cytoskeleton through N-WASP.[4]

Interactions

WASL (gene) has been shown to interact with RHOQ,[5] NCK1,[6] Profilin 1,[7][8] Cortactin[9] and CDC42.[1][10]

References

  1. ^ a b Miki H, Sasaki T, Takai Y, Takenawa T (Jan 1998). "Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP". Nature 391 (6662): 93–6. doi:10.1038/34208. PMID 9422512. 
  2. ^ Fukuoka M, Miki H, Takenawa T (Oct 1997). "Identification of N-WASP homologs in human and rat brain". Gene 196 (1–2): 43–8. doi:10.1016/S0378-1119(97)00184-4. PMID 9322739. 
  3. ^ a b "Entrez Gene: WASL Wiskott-Aldrich syndrome-like". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8976. 
  4. ^ Suetsugu S, Tezuka T, Morimura T, Hattori M, Mikoshiba K, Yamamoto T, Takenawa T (November 2004). "Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1". Biochem. J. 384 (Pt 1): 1–8. doi:10.1042/BJ20041103. PMC 1134082. PMID 15361067. http://www.biochemj.org/bj/384/0001/bj3840001.htm. 
  5. ^ Abe, Tomoyuki; Kato Masayoshi, Miki Hiroaki, Takenawa Tadaomi, Endo Takeshi (Jan. 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell. Sci. (England) 116 (Pt 1): 155–68. doi:10.1242/jcs.00208. ISSN 0021-9533. PMID 12456725. 
  6. ^ Rohatgi, R; Nollau P, Ho H Y, Kirschner M W, Mayer B J (Jul. 2001). "Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway". J. Biol. Chem. (United States) 276 (28): 26448–52. doi:10.1074/jbc.M103856200. ISSN 0021-9258. PMID 11340081. 
  7. ^ Mimuro, H; Suzuki T, Suetsugu S, Miki H, Takenawa T, Sasakawa C (Sep. 2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". J. Biol. Chem. (UNITED STATES) 275 (37): 28893–901. doi:10.1074/jbc.M003882200. ISSN 0021-9258. PMID 10867004. 
  8. ^ Suetsugu, S; Miki H, Takenawa T (Nov. 1998). "The essential role of profilin in the assembly of actin for microspike formation". EMBO J. (ENGLAND) 17 (22): 6516–26. doi:10.1093/emboj/17.22.6516. ISSN 0261-4189. PMC 1170999. PMID 9822597. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170999. 
  9. ^ Mizutani, Kiyohito; Miki Hiroaki, He Hong, Maruta Hiroshi, Takenawa Tadaomi (Feb. 2002). "Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts". Cancer Res. (United States) 62 (3): 669–74. ISSN 0008-5472. PMID 11830518. 
  10. ^ Carlier, M F; Nioche P, Broutin-L'Hermite I, Boujemaa R, Le Clainche C, Egile C, Garbay C, Ducruix A, Sansonetti P, Pantaloni D (Jul. 2000). "GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex". J. Biol. Chem. (UNITED STATES) 275 (29): 21946–52. doi:10.1074/jbc.M000687200. ISSN 0021-9258. PMID 10781580. 

Further reading




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