WIPF1

WAS/WASL interacting protein family, member 1, also known as WIPF1, is a human gene.cite web | title = Entrez Gene: WIPF1 WAS/WASL interacting protein family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7456| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.cite web | title = Entrez Gene: WIPF1 WAS/WASL interacting protein family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7456| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ramesh N, Antón IM, Martínez-Quiles N, Geha RS |title=Waltzing with WASP. |journal=Trends Cell Biol. |volume=9 |issue= 1 |pages= 15–9 |year= 1999 |pmid= 10087612 |doi=
*cite journal | author=Ramesh N, Antón IM, Hartwig JH, Geha RS |title=WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14671–6 |year= 1998 |pmid= 9405671 |doi=
*cite journal | author=Antón IM, Lu W, Mayer BJ, "et al." |title=The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. |journal=J. Biol. Chem. |volume=273 |issue= 33 |pages= 20992–5 |year= 1998 |pmid= 9694849 |doi=
*cite journal | author=Stewart DM, Tian L, Nelson DL |title=Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein. |journal=J. Immunol. |volume=162 |issue= 8 |pages= 5019–24 |year= 1999 |pmid= 10202051 |doi=
*cite journal | author=Vaduva G, Martinez-Quiles N, Anton IM, "et al." |title=The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17103–8 |year= 1999 |pmid= 10358064 |doi=
*cite journal | author=Moreau V, Frischknecht F, Reckmann I, "et al." |title=A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. |journal=Nat. Cell Biol. |volume=2 |issue= 7 |pages= 441–8 |year= 2000 |pmid= 10878810 |doi= 10.1038/35017080
*cite journal | author=Vetterkind S, Miki H, Takenawa T, "et al." |title=The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 87–95 |year= 2002 |pmid= 11687573 |doi= 10.1074/jbc.M104555200
*cite journal | author=Antón IM, de la Fuente MA, Sims TN, "et al." |title=WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. |journal=Immunity |volume=16 |issue= 2 |pages= 193–204 |year= 2002 |pmid= 11869681 |doi=
*cite journal | author=Scott MP, Zappacosta F, Kim EY, "et al." |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238–46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200
*cite journal | author=Benesch S, Lommel S, Steffen A, "et al." |title=Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37771–6 |year= 2002 |pmid= 12147689 |doi= 10.1074/jbc.M204145200
*cite journal | author=Zettl M, Way M |title=The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs. |journal=Curr. Biol. |volume=12 |issue= 18 |pages= 1617–22 |year= 2003 |pmid= 12372256 |doi=
*cite journal | author=Volkman BF, Prehoda KE, Scott JA, "et al." |title=Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. |journal=Cell |volume=111 |issue= 4 |pages= 565–76 |year= 2002 |pmid= 12437929 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sasahara Y, Rachid R, Byrne MJ, "et al." |title=Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. |journal=Mol. Cell |volume=10 |issue= 6 |pages= 1269–81 |year= 2003 |pmid= 12504004 |doi=
*cite journal | author=Luthi JN, Gandhi MJ, Drachman JG |title=X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP). |journal=Exp. Hematol. |volume=31 |issue= 2 |pages= 150–8 |year= 2003 |pmid= 12591280 |doi=
*cite journal | author=Kinley AW, Weed SA, Weaver AM, "et al." |title=Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. |journal=Curr. Biol. |volume=13 |issue= 5 |pages= 384–93 |year= 2003 |pmid= 12620186 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kim MK, Kim ES, Kim DS, "et al." |title=Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling. |journal=Biochim. Biophys. Acta |volume=1690 |issue= 2 |pages= 134–40 |year= 2004 |pmid= 15469902 |doi= 10.1016/j.bbadis.2004.06.007
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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