- CDK5R1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35), also known as CDK5R1, is a human
gene .cite web | title = Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8851| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.cite web | title = Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8851| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Peruzzi F, Gordon J, Darbinian N, Amini S |title=Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway. |journal=J. Neurovirol. |volume=8 Suppl 2 |issue= |pages= 91–6 |year= 2003 |pmid= 12491158 |doi= 10.1080/13550280290167885
*cite journal | author=Studzinski GP, Harrison JS |title=The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells. |journal=Leuk. Lymphoma |volume=44 |issue= 2 |pages= 235–40 |year= 2003 |pmid= 12688339 |doi=
*cite journal | author=Takahashi M, Tomizawa K, Sato K, "et al." |title=A novel tau-tubulin kinase from bovine brain. |journal=FEBS Lett. |volume=372 |issue= 1 |pages= 59–64 |year= 1995 |pmid= 7556643 |doi=
*cite journal | author=Tang D, Yeung J, Lee KY, "et al." |title=An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26897–903 |year= 1995 |pmid= 7592934 |doi=
*cite journal | author=Tsai LH, Delalle I, Caviness VS, "et al." |title=p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. |journal=Nature |volume=371 |issue= 6496 |pages= 419–23 |year= 1994 |pmid= 8090221 |doi= 10.1038/371419a0
*cite journal | author=Chae T, Kwon YT, Bronson R, "et al." |title=Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. |journal=Neuron |volume=18 |issue= 1 |pages= 29–42 |year= 1997 |pmid= 9010203 |doi=
*cite journal | author=Poon RY, Lew J, Hunter T |title=Identification of functional domains in the neuronal Cdk5 activator protein. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5703–8 |year= 1997 |pmid= 9038181 |doi=
*cite journal | author=Fletcher AI, Shuang R, Giovannucci DR, "et al." |title=Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4027–35 |year= 1999 |pmid= 9933594 |doi=
*cite journal | author=Patrick GN, Zukerberg L, Nikolic M, "et al." |title=Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. |journal=Nature |volume=402 |issue= 6762 |pages= 615–22 |year= 2000 |pmid= 10604467 |doi= 10.1038/45159
*cite journal | author=Ching YP, Qi Z, Wang JH |title=Cloning of three novel neuronal Cdk5 activator binding proteins. |journal=Gene |volume=242 |issue= 1-2 |pages= 285–94 |year= 2000 |pmid= 10721722 |doi=
*cite journal | author=Kwon YT, Gupta A, Zhou Y, "et al." |title=Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. |journal=Curr. Biol. |volume=10 |issue= 7 |pages= 363–72 |year= 2000 |pmid= 10753743 |doi=
*cite journal | author=Lee MS, Kwon YT, Li M, "et al." |title=Neurotoxicity induces cleavage of p35 to p25 by calpain. |journal=Nature |volume=405 |issue= 6784 |pages= 360–4 |year= 2000 |pmid= 10830966 |doi= 10.1038/35012636
*cite journal | author=Wang X, Ching YP, Lam WH, "et al." |title=Identification of a common protein association region in the neuronal Cdk5 activator. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31763–9 |year= 2000 |pmid= 10915792 |doi= 10.1074/jbc.M004358200
*cite journal | author=Floyd SR, Porro EB, Slepnev VI, "et al." |title=Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8104–10 |year= 2001 |pmid= 11113134 |doi= 10.1074/jbc.M008932200
*cite journal | author=Kesavapany S, Lau KF, McLoughlin DM, "et al." |title=p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction. |journal=Eur. J. Neurosci. |volume=13 |issue= 2 |pages= 241–7 |year= 2001 |pmid= 11168528 |doi=
*cite journal | author=Chen F, Studzinski GP |title=Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. |journal=Blood |volume=97 |issue= 12 |pages= 3763–7 |year= 2001 |pmid= 11389014 |doi=
*cite journal | author=Tarricone C, Dhavan R, Peng J, "et al." |title=Structure and regulation of the CDK5-p25(nck5a) complex. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 657–69 |year= 2001 |pmid= 11583627 |doi=
*cite journal | author=Rashid T, Banerjee M, Nikolic M |title=Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 49043–52 |year= 2002 |pmid= 11604394 |doi= 10.1074/jbc.M105599200
*cite journal | author=Qu D, Li Q, Lim HY, "et al." |title=The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7324–32 |year= 2002 |pmid= 11741927 |doi= 10.1074/jbc.M107270200
*cite journal | author=Patzke H, Tsai LH |title=Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8054–60 |year= 2002 |pmid= 11784720 |doi= 10.1074/jbc.M109645200PBB_Controls
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