- CDK5R2
Cyclin-dependent kinase 5, regulatory subunit 2 (p39), also known as CDK5R2, is a human
gene .cite web | title = Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8941| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins.cite web | title = Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8941| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Tang D, Yeung J, Lee KY, "et al." |title=An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26897–903 |year= 1995 |pmid= 7592934 |doi=
*cite journal | author=Humbert S, Dhavan R, Tsai L |title=p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. |journal=J. Cell. Sci. |volume=113 ( Pt 6) |issue= |pages= 975–83 |year= 2000 |pmid= 10683146 |doi=
*cite journal | author=Humbert S, Lanier LM, Tsai LH |title=Synaptic localization of p39, a neuronal activator of cdk5. |journal=Neuroreport |volume=11 |issue= 10 |pages= 2213–6 |year= 2001 |pmid= 10923673 |doi=
*cite journal | author=Muravenko OV, Gizatullin RZ, Protopopov AI, "et al." |title=Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 3-4 |pages= 160–1 |year= 2000 |pmid= 10965112 |doi=
*cite journal | author=Agarwal-Mawal A, Paudel HK |title=Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23712–8 |year= 2001 |pmid= 11320080 |doi= 10.1074/jbc.M010002200
*cite journal | author=Patzke H, Tsai LH |title=Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8054–60 |year= 2002 |pmid= 11784720 |doi= 10.1074/jbc.M109645200
*cite journal | author=Dhavan R, Greer PL, Morabito MA, "et al." |title=The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. |journal=J. Neurosci. |volume=22 |issue= 18 |pages= 7879–91 |year= 2002 |pmid= 12223541 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sakashita G, Shima H, Komatsu M, "et al." |title=Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 165–71 |year= 2004 |pmid= 12761178 |doi=
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Rademakers R, Sleegers K, Theuns J, "et al." |title=Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. |journal=Neurobiol. Aging |volume=26 |issue= 8 |pages= 1145–51 |year= 2005 |pmid= 15917097 |doi= 10.1016/j.neurobiolaging.2004.10.003PBB_Controls
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