Diiodotyrosine transaminase

Diiodotyrosine transaminase
diiodotyrosine transaminase
Identifiers
EC number 2.6.1.24
CAS number 9033-18-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diiodotyrosine transaminase (EC 2.6.1.24) is an enzyme that catalyzes the chemical reaction

3,5-diiodo-L-tyrosine + 2-oxoglutarate \rightleftharpoons 4-hydroxy-3,5-diiodophenylpyruvate + L-glutamate

Thus, the two substrates of this enzyme are 3,5-diiodo-L-tyrosine and 2-oxoglutarate, whereas its two products are 4-hydroxy-3,5-diiodophenylpyruvate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase. Other names in common use include diiodotyrosine aminotransferase, halogenated tyrosine aminotransferase, and halogenated tyrosine transaminase. It employs one cofactor, pyridoxal phosphate.

References

  • Nakano M (1967). "Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria". J. Biol. Chem. 242 (1): 73–81. PMID 4381052. 
  • Nakano M and Danowski TS (1964). "Thyroid-hormone transaminase and oxidase in rat-kidney mitochondria". Biochim. Biophys. Acta 85: 18–28. PMID 14159298. 
v · d · eTransferase: nitrogenous groups (EC 2.6)
2.6.1: Transaminases
2.6.3: Oximinotransferases
2.6.99: Other
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
v · Thyroid hormone metabolism enzymes and transporters
Enzymes
Thyroid peroxidase · Iodotyrosine deiodinase · Dual oxidase 1/Dual oxidase 2 · Iodothyronine deiodinase · Diiodotyrosine transaminase
Transporters

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)


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