Dihydroxyphenylalanine transaminase

dihydroxyphenylalanine transaminase
Identifiers
EC number	2.6.1.49
CAS number	37277-98-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a dihydroxyphenylalanine transaminase (EC 2.6.1.49) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxy-L-phenylalanine + 2-oxoglutarate $\rightleftharpoons$ 3,4-dihydroxyphenylpyruvate + L-glutamate

Thus, the two substrates of this enzyme are 3,4-dihydroxy-L-phenylalanine and 2-oxoglutarate, whereas its two products are 3,4-dihydroxyphenylpyruvate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase. Other names in common use include dopa transaminase, dihydroxyphenylalanine aminotransferase, aspartate-DOPP transaminase (ADT), L-dopa transaminase, dopa aminotransferase, glutamate-DOPP transaminase (GDT), phenylalanine-DOPP transaminase (PDT), DOPA 2-oxoglutarate aminotransferase, and DOPAATS. This enzyme participates in tyrosine metabolism. It employs one cofactor, pyridoxal phosphate.

References

• Fonnum F, Larsen K (1965). "Purification and properties of dihydroxyphenylalanine transaminase from guinea pig brain". J. Neurochem. 12 (7): 589–98. doi:10.1111/j.1471-4159.1965.tb04251.x. PMID 5829872. 

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