MAP4K1

Mitogen-activated protein kinase kinase kinase kinase 1
Identifiers
Symbols	MAP4K1; HPK1
External IDs	OMIM: 601983 MGI: 1346882 HomoloGene: 5199 GeneCards: MAP4K1 Gene
EC number	2.7.11.1
Gene Ontology Molecular function • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • small GTPase regulator activity • protein binding • ATP binding • MAP kinase kinase kinase kinase activity Biological process • activation of MAPKKK activity • protein phosphorylation • response to stress • intracellular protein kinase cascade • activation of JUN kinase activity • peptidyl-serine phosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11184	26411
Ensembl	ENSG00000104814	ENSMUSG00000037337
UniProt	Q92918	Q3UJX3
RefSeq (mRNA)	NM_001042600.1	NM_008279.2
RefSeq (protein)	NP_001036065.1	NP_032305.2
Location (UCSC)	Chr 19: 39.08 – 39.11 Mb	Chr 7: 29.77 – 29.79 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.^[1]. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).

Interactions

MAP4K1 has been shown to interact with B-cell linker,^[2] Grb2,^[3][4][5][6] CRKL,^[3][5][6] Drebrin-like,^[7] CRK,^[3][5][6] Linker of activated T cells,^[6] NCK1^[4][5][6] and GRAP2.^[8]

References

1. ^ Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585. 
2. ^ Tsuji, S; Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D (Aug. 2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. (United States) 194 (4): 529–39. doi:10.1084/jem.194.4.529. ISSN 0022-1007. PMC 2193495. PMID 11514608. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193495. 
3. ^ ^{a b c} Oehrl, W; Kardinal C, Ruf S, Adermann K, Groffen J, Feng G S, Blenis J, Tan T H, Feller S M (Oct. 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene (ENGLAND) 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. ISSN 0950-9232. PMID 9788432. 
4. ^ ^{a b} Anafi, M; Kiefer F, Gish G D, Mbamalu G, Iscove N N, Pawson T (Oct. 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. (UNITED STATES) 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. ISSN 0021-9258. PMID 9346925. 
5. ^ ^{a b c d} Ling, P; Yao Z, Meyer C F, Wang X S, Oehrl W, Feller S M, Tan T H (Feb. 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1359–68. ISSN 0270-7306. PMC 116064. PMID 9891069. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=116064. 
6. ^ ^{a b c d e} Ling, P; Meyer C F, Redmond L P, Shui J W, Davis B, Rich R R, Hu M C, Wange R L, Tan T H (Jun. 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. (United States) 276 (22): 18908–14. doi:10.1074/jbc.M101485200. ISSN 0021-9258. PMID 11279207. 
7. ^ Ensenat, D; Yao Z, Wang X S, Kori R, Zhou G, Lee S C, Tan T H (Nov. 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. (UNITED STATES) 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. ISSN 0021-9258. PMID 10567356. 
8. ^ Ma, W; Xia C, Ling P, Qiu M, Luo Y, Tan T H, Liu M (Mar. 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene (England) 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. ISSN 0950-9232. PMID 11313918.