Linker of activated T cells

Linker of activated T cells

Linker of Activated T cells (LAT) is a transmembrane adapter protein associated with glycosphingolipid-enriched microdomains (GEMs).cite journal | author = Horejsí V | title = Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling | journal = Immunol. Lett. | volume = 92 | issue = 1-2 | pages = 43–9 | year = 2004 | pmid = 15081526 | doi = 10.1016/j.imlet.2003.10.013 | issn = ]

LAT was described in the early 1990s as a phosphoprotein of 36–38 kDa (pp. 36–38) rapidly phosphorylated on tyrosine residues following TCR ligation.cite journal | author = Sieh M, Batzer A, Schlessinger J, Weiss A | title = GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation | journal = Mol. Cell. Biol. | volume = 14 | issue = 7 | pages = 4435–42 | year = 1994 | pmid = 7516467 | doi = | issn = ] Cloning of the gene revealed that the protein product is a type III (leaderless) transmembrane protein of 262 aminoacids (long form) or 233 aminoacids (short form) in humans, 242 aminoacids in mouse, and 241 aminoacids in rat.cite journal | author = Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE | title = LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation | journal = Cell | volume = 92 | issue = 1 | pages = 83–92 | year = 1998 | pmid = 9489702 | doi = 10.1016/S0092-8674(00)80901-0 | issn = ] cite journal | author = Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT | title = Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells | journal = J. Exp. Med. | volume = 187 | issue = 7 | pages = 1157–61 | year = 1998 | pmid = 9529333 | doi = 10.1084/jem.187.7.1157 | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wange RL |title=LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. |journal=Sci. STKE |volume=2000 |issue= 63 |pages= RE1 |year= 2002 |pmid= 11752630 |doi= 10.1126/stke.2000.63.re1
*cite journal | author=Sommers CL, Samelson LE, Love PE |title=LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. |journal=Bioessays |volume=26 |issue= 1 |pages= 61-7 |year= 2004 |pmid= 14696041 |doi= 10.1002/bies.10384
*cite journal | author=Rivera J |title=NTAL/LAB and LAT: a balancing act in mast-cell activation and function. |journal=Trends Immunol. |volume=26 |issue= 3 |pages= 119-22 |year= 2005 |pmid= 15745852 |doi= 10.1016/j.it.2005.01.001
*cite journal | author=Trüb T, Frantz JD, Miyazaki M, "et al." |title=The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 894-902 |year= 1997 |pmid= 8995379 |doi=
*cite journal | author=Hendricks-Taylor LR, Motto DG, Zhang J, "et al." |title=SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1363-7 |year= 1997 |pmid= 8995445 |doi=
*cite journal | author=Zhang W, Sloan-Lancaster J, Kitchen J, "et al." |title=LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. |journal=Cell |volume=92 |issue= 1 |pages= 83-92 |year= 1998 |pmid= 9489702 |doi=
*cite journal | author=Weber JR, Orstavik S, Torgersen KM, "et al." |title=Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. |journal=J. Exp. Med. |volume=187 |issue= 7 |pages= 1157-61 |year= 1998 |pmid= 9529333 |doi=
*cite journal | author=Zhang W, Trible RP, Samelson LE |title=LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. |journal=Immunity |volume=9 |issue= 2 |pages= 239-46 |year= 1998 |pmid= 9729044 |doi=
*cite journal | author=Finco TS, Kadlecek T, Zhang W, "et al." |title=LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. |journal=Immunity |volume=9 |issue= 5 |pages= 617-26 |year= 1998 |pmid= 9846483 |doi=
*cite journal | author=Sarkar S |title=Tyrosine phosphorylation and translocation of LAT in platelets. |journal=FEBS Lett. |volume=441 |issue= 3 |pages= 357-60 |year= 1999 |pmid= 9891970 |doi=
*cite journal | author=Liu SK, Fang N, Koretzky GA, McGlade CJ |title=The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. |journal=Curr. Biol. |volume=9 |issue= 2 |pages= 67-75 |year= 1999 |pmid= 10021361 |doi=
*cite journal | author=Jevremovic D, Billadeau DD, Schoon RA, "et al." |title=Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. |journal=J. Immunol. |volume=162 |issue= 5 |pages= 2453-6 |year= 1999 |pmid= 10072481 |doi=
*cite journal | author=Zhang W, Sommers CL, Burshtyn DN, "et al." |title=Essential role of LAT in T cell development. |journal=Immunity |volume=10 |issue= 3 |pages= 323-32 |year= 1999 |pmid= 10204488 |doi=
*cite journal | author=Tang J, Sawasdikosol S, Chang JH, Burakoff SJ |title=SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9775-80 |year= 1999 |pmid= 10449770 |doi=
*cite journal | author=Gross BS, Melford SK, Watson SP |title=Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 612-23 |year= 1999 |pmid= 10469124 |doi=
*cite journal | author=Lindholm CK, Gylfe E, Zhang W, "et al." |title=Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 28050-7 |year= 1999 |pmid= 10488157 |doi=
*cite journal | author=Shan X, Wange RL |title=Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29323-30 |year= 1999 |pmid= 10506192 |doi=
*cite journal | author=Bosselut R, Zhang W, Ashe JM, "et al." |title=Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction. |journal=J. Exp. Med. |volume=190 |issue= 10 |pages= 1517-26 |year= 1999 |pmid= 10562325 |doi=
*cite journal | author=Tridandapani S, Lyden TW, Smith JL, "et al." |title=The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20480-7 |year= 2000 |pmid= 10781611 |doi= 10.1074/jbc.M909462199
*cite journal | author=Zhang W, Trible RP, Zhu M, "et al." |title=Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23355-61 |year= 2000 |pmid= 10811803 |doi= 10.1074/jbc.M000404200

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