GRAP2

GRB2-related adaptor protein 2, also known as GRAP2, is a human gene.cite web | title = Entrez Gene: GRAP2 GRB2-related adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9402| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.cite web | title = Entrez Gene: GRAP2 GRB2-related adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9402| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bourette RP, Arnaud S, Myles GM, "et al." |title=Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7273–81 |year= 1999 |pmid= 9857184 |doi= 10.1093/emboj/17.24.7273
*cite journal | author=Liu SK, McGlade CJ |title=Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc. |journal=Oncogene |volume=17 |issue= 24 |pages= 3073–82 |year= 1999 |pmid= 9872323 |doi= 10.1038/sj.onc.1202337
*cite journal | author=Qiu M, Hua S, Agrawal M, "et al." |title=Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 443–7 |year= 1999 |pmid= 9878555 |doi= 10.1006/bbrc.1998.9795
*cite journal | author=Liu SK, Fang N, Koretzky GA, McGlade CJ |title=The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. |journal=Curr. Biol. |volume=9 |issue= 2 |pages= 67–75 |year= 1999 |pmid= 10021361 |doi=
*cite journal | author=Law CL, Ewings MK, Chaudhary PM, "et al." |title=GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. |journal=J. Exp. Med. |volume=189 |issue= 8 |pages= 1243–53 |year= 1999 |pmid= 10209041 |doi=
*cite journal | author=Asada H, Ishii N, Sasaki Y, "et al." |title=Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. |journal=J. Exp. Med. |volume=189 |issue= 9 |pages= 1383–90 |year= 1999 |pmid= 10224278 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Xia C, Bao Z, Tabassam F, "et al." |title=GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20942–8 |year= 2000 |pmid= 10801854 |doi= 10.1074/jbc.M002598200
*cite journal | author=Zhang W, Trible RP, Zhu M, "et al." |title=Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23355–61 |year= 2000 |pmid= 10811803 |doi= 10.1074/jbc.M000404200
*cite journal | author=Ellis JH, Ashman C, Burden MN, "et al." |title=GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5805–14 |year= 2000 |pmid= 10820259 |doi=
*cite journal | author=Ma W, Xia C, Ling P, "et al." |title=Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. |journal=Oncogene |volume=20 |issue= 14 |pages= 1703–14 |year= 2001 |pmid= 11313918 |doi= 10.1038/sj.onc.1204224
*cite journal | author=Poetsch A, Molday LL, Molday RS |title=The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48009–16 |year= 2002 |pmid= 11641407 |doi= 10.1074/jbc.M108941200
*cite journal | author=Wenzel J, Sanzenbacher R, Ghadimi M, "et al." |title=Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. |journal=FEBS Lett. |volume=509 |issue= 2 |pages= 255–62 |year= 2002 |pmid= 11741599 |doi=
*cite journal | author=Bourgin C, Bourette RP, Arnaud S, "et al." |title=Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3744–56 |year= 2002 |pmid= 11997510 |doi=
*cite journal | author=Guyot B, Arnaud S, Phothirath P, "et al." |title=Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters. |journal=Gene |volume=290 |issue= 1-2 |pages= 173–9 |year= 2002 |pmid= 12062812 |doi=
*cite journal | author=Lindholm CK, Henriksson ML, Hallberg B, Welsh M |title=Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells. |journal=Eur. J. Biochem. |volume=269 |issue= 13 |pages= 3279–88 |year= 2002 |pmid= 12084069 |doi=
*cite journal | author=Zhu M, Janssen E, Leung K, Zhang W |title=Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46151–8 |year= 2003 |pmid= 12359715 |doi= 10.1074/jbc.M208946200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Guyot B, Arnaud S, Phothirath P, "et al." |title=Upstream open reading frames regulate translation of Mona/Gads adapter mRNA in the megakaryocytic lineage. |journal=Platelets |volume=13 |issue= 8 |pages= 459–64 |year= 2003 |pmid= 12487779 |doi= 10.1080/0953710021000059431
*cite journal | author=Yankee TM, Solow SA, Draves KD, Clark EA |title=Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways. |journal=J. Immunol. |volume=170 |issue= 1 |pages= 349–55 |year= 2003 |pmid= 12496419 |doi=

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