CRKL

V-crk sarcoma virus CT10 oncogene homolog (avian)-like, also known as CRKL, is a human gene.

PBB_Summary
section_title =
summary_text = v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. [cite web | title = Entrez Gene: CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1399| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Feller SM, Posern G, Voss J, "et al." |title=Physiological signals and oncogenesis mediated through Crk family adapter proteins. |journal=J. Cell. Physiol. |volume=177 |issue= 4 |pages= 535–52 |year= 1999 |pmid= 10092207 |doi= 10.1002/(SICI)1097-4652(199812)177:4<535::AID-JCP5>3.0.CO;2-E |doilabel=10.1002/(SICI)1097-4652(199812)177:4535::AID-JCP53.0.CO;2-E
*cite journal | author=Salgia R, Uemura N, Okuda K, "et al." |title=CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. |journal=J. Biol. Chem. |volume=270 |issue= 49 |pages= 29145–50 |year= 1996 |pmid= 7493940 |doi=
*cite journal | author=Ren R, Ye ZS, Baltimore D |title=Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. |journal=Genes Dev. |volume=8 |issue= 7 |pages= 783–95 |year= 1994 |pmid= 7926767 |doi=
*cite journal | author=Oda T, Heaney C, Hagopian JR, "et al." |title=Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. |journal=J. Biol. Chem. |volume=269 |issue= 37 |pages= 22925–8 |year= 1994 |pmid= 8083188 |doi=
*cite journal | author=ten Hoeve J, Morris C, Heisterkamp N, Groffen J |title=Isolation and chromosomal localization of CRKL, a human crk-like gene. |journal=Oncogene |volume=8 |issue= 9 |pages= 2469–74 |year= 1993 |pmid= 8361759 |doi=
*cite journal | author=Smit L, van der Horst G, Borst J |title=Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8564–9 |year= 1996 |pmid= 8621483 |doi=
*cite journal | author=Senechal K, Halpern J, Sawyers CL |title=The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23255–61 |year= 1996 |pmid= 8798523 |doi=
*cite journal | author=Salgia R, Pisick E, Sattler M, "et al." |title=p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25198–203 |year= 1996 |pmid= 8810278 |doi=
*cite journal | author=Ingham RJ, Krebs DL, Barbazuk SM, "et al." |title=B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins. |journal=J. Biol. Chem. |volume=271 |issue= 50 |pages= 32306–14 |year= 1997 |pmid= 8943292 |doi=
*cite journal | author=Heaney C, Kolibaba K, Bhat A, "et al." |title=Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation. |journal=Blood |volume=89 |issue= 1 |pages= 297–306 |year= 1997 |pmid= 8978305 |doi=
*cite journal | author=Manié SN, Beck AR, Astier A, "et al." |title=Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4230–6 |year= 1997 |pmid= 9020138 |doi=
*cite journal | author=de Jong R, ten Hoeve J, Heisterkamp N, Groffen J |title=Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. |journal=Oncogene |volume=14 |issue= 5 |pages= 507–13 |year= 1997 |pmid= 9053848 |doi= 10.1038/sj.onc.1200885
*cite journal | author=Uemura N, Salgia R, Li JL, "et al." |title=The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins. |journal=Leukemia |volume=11 |issue= 3 |pages= 376–85 |year= 1997 |pmid= 9067577 |doi=
*cite journal | author=Sattler M, Salgia R, Shrikhande G, "et al." |title=Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL). |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10248–53 |year= 1997 |pmid= 9092574 |doi=
*cite journal | author=Sattler M, Salgia R, Shrikhande G, "et al." |title=Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14320–6 |year= 1997 |pmid= 9162067 |doi=
*cite journal | author=Husson H, Mograbi B, Schmid-Antomarchi H, "et al." |title=CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2. |journal=Oncogene |volume=14 |issue= 19 |pages= 2331–8 |year= 1997 |pmid= 9178909 |doi= 10.1038/sj.onc.1201074
*cite journal | author=Chin H, Saito T, Arai A, "et al." |title=Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 412–7 |year= 1997 |pmid= 9344843 |doi= 10.1006/bbrc.1997.7480
*cite journal | author=Ahmad S, Alsayed YM, Druker BJ, Platanias LC |title=The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 29991–4 |year= 1997 |pmid= 9374471 |doi=
*cite journal | author=de Jong R, van Wijk A, Haataja L, "et al." |title=BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32649–55 |year= 1998 |pmid= 9405482 |doi=
*cite journal | author=Gesbert F, Garbay C, Bertoglio J |title=Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells. |journal=J. Biol. Chem. |volume=273 |issue= 7 |pages= 3986–93 |year= 1998 |pmid= 9461587 |doi=

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