PIK3R2

Phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Rendering based on PDB 2KT1.
Available structures PDB 2KT1, 3MTT
Identifiers
Symbols	PIK3R2; P85B; p85; p85-BETA
External IDs	OMIM: 603157 MGI: 1098772 HomoloGene: 3687 GeneCards: PIK3R2 Gene
Gene Ontology Molecular function • GTPase activator activity • protein binding • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol 3-kinase regulator activity Cellular component • intracellular • cytosol • cytosol • phosphatidylinositol 3-kinase complex Biological process • signal transduction • small GTPase mediated signal transduction • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • negative regulation of anti-apoptosis • platelet activation • T cell costimulation • positive regulation of GTPase activity • nerve growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • T cell receptor signaling pathway • leukocyte migration • regulation of small GTPase mediated signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5296	18709
Ensembl	ENSG00000105647	ENSMUSG00000031834
UniProt	O00459	Q3UK33
RefSeq (mRNA)	NM_005027.2	NM_008841.2
RefSeq (protein)	NP_005018.1	NP_032867.2
Location (UCSC)	Chr 19: 18.26 – 18.28 Mb	Chr 8: 73.29 – 73.3 Mb
PubMed search	[1]	[2]

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.^[1][2]

Interactions

PIK3R2 has been shown to interact with FYN,^[3] HER2/neu,^[3] Epidermal growth factor,^[3] Cbl gene,^[4][5] PIK3CD,^[6] CRKL^[7] and Macrophage colony-stimulating factor.^[3]

References

1. ^ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, Bernardi F, Rooke L, Waterfield MD (May 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene 7 (4): 789–93. PMID 1314371. 
2. ^ "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=5296&rn=1. 
3. ^ ^{a b c d} Gout, I; Dhand R, Panayotou G, Fry M J, Hiles I, Otsu M, Waterfield M D (Dec. 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". Biochem. J. (ENGLAND) 288 ( Pt 2): 395–405. ISSN 0264-6021. PMC 1132024. PMID 1334406. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1132024. 
4. ^ Lin, H; Martelli M P, Bierer B E (Jan. 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". Int. Immunol. (England) 13 (1): 13–22. doi:10.1093/intimm/13.1.13. ISSN 0953-8178. PMID 11133830. 
5. ^ Hartley, D; Meisner H, Corvera S (Aug. 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". J. Biol. Chem. (UNITED STATES) 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. ISSN 0021-9258. PMID 7629144. 
6. ^ Vanhaesebroeck, B; Welham M J, Kotani K, Stein R, Warne P H, Zvelebil M J, Higashi K, Volinia S, Downward J, Waterfield M D (Apr. 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. ISSN 0027-8424. PMC 20722. PMID 9113989. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20722. 
7. ^ Sattler, M; Salgia R, Shrikhande G, Verma S, Pisick E, Prasad K V, Griffin J D (Apr. 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". J. Biol. Chem. (UNITED STATES) 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. ISSN 0021-9258. PMID 9092574. 

Further reading

• Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231. 
• Gout I, Dhand R, Panayotou G, et al. (1993). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.". Biochem. J. 288 ( Pt 2): 395–405. PMC 1132024. PMID 1334406. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1132024. 
• Carpenter CL, Duckworth BC, Auger KR, et al. (1991). "Purification and characterization of phosphoinositide 3-kinase from rat liver.". J. Biol. Chem. 265 (32): 19704–11. PMID 2174051. 
• Truitt KE, Hicks CM, Imboden JB (1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.". J. Exp. Med. 179 (3): 1071–6. doi:10.1084/jem.179.3.1071. PMC 2191424. PMID 7509360. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2191424. 
• Herbst R, Shearman MS, Jallal B, et al. (1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro.". Biochemistry 34 (17): 5971–9. doi:10.1021/bi00017a026. PMID 7537096. 
• Craparo A, O'Neill TJ, Gustafson TA (1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.". J. Biol. Chem. 270 (26): 15639–43. doi:10.1074/jbc.270.26.15639. PMID 7541045. 
• He W, O'Neill TJ, Gustafson TA (1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.". J. Biol. Chem. 270 (40): 23258–62. doi:10.1074/jbc.270.40.23258. PMID 7559478. 
• Kapeller R, Toker A, Cantley LC, Carpenter CL (1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.". J. Biol. Chem. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789. 
• Hartley D, Meisner H, Corvera S (1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl.". J. Biol. Chem. 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. PMID 7629144. 
• Pandey A, Lazar DF, Saltiel AR, Dixit VM (1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.". J. Biol. Chem. 269 (48): 30154–7. PMID 7982920. 
• August A, Dupont B (1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase.". Int. Immunol. 6 (5): 769–74. doi:10.1093/intimm/6.5.769. PMID 8080844. 
• Fukazawa T, Miyake S, Band V, Band H (1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.". J. Biol. Chem. 271 (24): 14554–9. doi:10.1074/jbc.271.24.14554. PMID 8662998. 
• Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.". J. Biol. Chem. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481. 
• Sattler M, Salgia R, Shrikhande G, et al. (1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).". J. Biol. Chem. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574. 
• Vanhaesebroeck B, Welham MJ, Kotani K, et al. (1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20722. 
• Briand G, Barbeau B, Tremblay M (1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase.". Virology 228 (2): 171–9. doi:10.1006/viro.1996.8399. PMID 9123823. 
• Braunger J, Schleithoff L, Schulz AS, et al. (1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.". Oncogene 14 (22): 2619–31. doi:10.1038/sj.onc.1201123. PMID 9178760. 
• Shepherd PR, Navé BT, Rincon J, et al. (1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.". J. Biol. Chem. 272 (30): 19000–7. doi:10.1074/jbc.272.30.19000. PMID 9228082. 
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793.