B-cell linker

B-cell linker

B-cell linker, also known as BLNK, is a human gene.cite web | title = Entrez Gene: BLNK B-cell linker| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29760| accessdate = ]

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summary_text = Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development. [supplied by OMIM] cite web | title = Entrez Gene: BLNK B-cell linker| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29760| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Fu C, Chan AC |title=Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27362–8 |year= 1997 |pmid= 9341187 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Fu C, Turck CW, Kurosaki T, Chan AC |title=BLNK: a central linker protein in B cell activation. |journal=Immunity |volume=9 |issue= 1 |pages= 93–103 |year= 1998 |pmid= 9697839 |doi=
*cite journal | author=Wienands J, Schweikert J, Wollscheid B, "et al." |title=SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. |journal=J. Exp. Med. |volume=188 |issue= 4 |pages= 791–5 |year= 1998 |pmid= 9705962 |doi=
*cite journal | author=Hashimoto S, Iwamatsu A, Ishiai M, "et al." |title=Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. |journal=Blood |volume=94 |issue= 7 |pages= 2357–64 |year= 1999 |pmid= 10498607 |doi=
*cite journal | author=Su YW, Zhang Y, Schweikert J, "et al." |title=Interaction of SLP adaptors with the SH2 domain of Tec family kinases. |journal=Eur. J. Immunol. |volume=29 |issue= 11 |pages= 3702–11 |year= 1999 |pmid= 10556826 |doi=
*cite journal | author=Minegishi Y, Rohrer J, Coustan-Smith E, "et al." |title=An essential role for BLNK in human B cell development. |journal=Science |volume=286 |issue= 5446 |pages= 1954–7 |year= 1999 |pmid= 10583958 |doi=
*cite journal | author=Fusaki N, Tomita S, Wu Y, "et al." |title=BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking. |journal=Eur. J. Immunol. |volume=30 |issue= 5 |pages= 1326–30 |year= 2000 |pmid= 10820378 |doi=
*cite journal | author=Mizuno K, Tagawa Y, Mitomo K, "et al." |title=Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells. |journal=J. Immunol. |volume=165 |issue= 3 |pages= 1344–51 |year= 2000 |pmid= 10903736 |doi=
*cite journal | author=Guo B, Kato RM, Garcia-Lloret M, "et al." |title=Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex. |journal=Immunity |volume=13 |issue= 2 |pages= 243–53 |year= 2000 |pmid= 10981967 |doi=
*cite journal | author=Watanabe S, Take H, Takeda K, "et al." |title=Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 1 |pages= 167–74 |year= 2001 |pmid= 11071869 |doi= 10.1006/bbrc.2000.3760
*cite journal | author=Tan JE, Wong SC, Gan SK, "et al." |title=The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20055–63 |year= 2001 |pmid= 11274146 |doi= 10.1074/jbc.M010800200
*cite journal | author=Adachi T, Wienands J, Wakabayashi C, "et al." |title=SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26648–55 |year= 2001 |pmid= 11356834 |doi= 10.1074/jbc.M100997200
*cite journal | author=Engels N, Wollscheid B, Wienands J |title=Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha. |journal=Eur. J. Immunol. |volume=31 |issue= 7 |pages= 2126–34 |year= 2001 |pmid= 11449366 |doi=
*cite journal | author=Sauer K, Liou J, Singh SB, "et al." |title=Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45207–16 |year= 2002 |pmid= 11487585 |doi= 10.1074/jbc.M106811200
*cite journal | author=Engels N, Merchant M, Pappu R, "et al." |title=Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module. |journal=J. Exp. Med. |volume=194 |issue= 3 |pages= 255–64 |year= 2001 |pmid= 11489945 |doi=
*cite journal | author=Tsuji S, Okamoto M, Yamada K, "et al." |title=B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. |journal=J. Exp. Med. |volume=194 |issue= 4 |pages= 529–39 |year= 2001 |pmid= 11514608 |doi=
*cite journal | author=Kabak S, Skaggs BJ, Gold MR, "et al." |title=The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2524–35 |year= 2002 |pmid= 11909947 |doi=
*cite journal | author=Yasuda T, Tezuka T, Maeda A, "et al." |title=Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. |journal=J. Exp. Med. |volume=196 |issue= 1 |pages= 51–63 |year= 2002 |pmid= 12093870 |doi=

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