Chiron Corporation

Chiron Corporation

Type	Subsidiary
Industry	Biotechnology
Fate	acquired as a subsidiary of Novartis
Founded	1981
Headquarters	Emeryville, California, USA
Products	Biopharmaceuticals, vaccines, blood testing
Revenue	$1.921 billion (2005)
Employees	5,400 (2005)
Parent	Novartis
Website	www.chiron.com

Chiron Corporation was a multinational biotechnology firm based in Emeryville, California that was acquired by Novartis International AG on April 20, 2006. It had offices and facilities in eighteen countries on five continents. Chiron's business and research was in three main areas: biopharmaceuticals, vaccines and blood testing. Chiron's vaccines and blood testing units have been combined to form Novartis Vaccines and Diagnostics, while Chiron BioPharmaceuticals will be integrated into Novartis Pharmaceuticals.

Early history

Chiron (pronounced KY-ron after the centaur from Greek mythology)^[1] was founded in 1981 by chairman, William J. Rutter, president and chief executive, Professor Edward Penhoet, and vice president for research, Pablo DT Valenzuela. All were academics from the University of California; Penhoet at Berkeley, where he continued to lecture, and the others from San Francisco.^[1] Chiron formed a partnership with the Swiss pharmaceutical giant, Ciba-Geigy Ltd.,^[1] through the Biocine Company,^[2][3] to use genetic engineering to develop vaccines and to treat, prevent and diagnose diseases such as AIDS, herpes and malaria.^[1][4] Other partnerships included Thicon Inc. to develop a growth factor hormone for the treatment of wounds and Merck & Co to develop an improvement to their existing hepatitis B vaccine.^[1] In 1986, Professor Penhoet said: "Our business strategy is to dominate small markets rather than take a small presence in a broad market." The niche that Chiron was focusing on was ophthalmology, which Mr. Penhoet said was "big enough to be interesting, but small enough to service with 40 salespeople." ^[1] Professor Penhoet also stated that Chiron was set up to provide the enabling technology for others to use under license,^[1] and later saying that Chiron was "as close to a virtual corporation as you can be", with few fixed assets but more relationships.^[5]

Expansion

In 1988, Chiron formed a joint venture company, called Mimesys Inc., with Johnson & Johnson and the Warner-Lambert Company, to develop the next generation of biotech drugs.^[6] The following year Chiron recruited Gregory Lawless, who had come from DuPont, to take over as president and CEO.^[7] This led to additional buying that included the acquisition of Du Pont in partnership with Ortho Diagnostic Systems;^[8] Munich based Adatomed G.m.b.H.;^[9] and a merger with fellow biotech company Cetus Corporation^[10] after Cetus failed to get approval for its drug Interleukin-2.^[11] Hollings Renton of Cetus became president and CEO when Gregory Lawless agreed to leave.^[2] Mr Renton resigned in 1992^[12] and was replaced by Sean Lance, from Glaxo Wellcome in 1998,^[13] and finally by Howard Pien from GlaxoSmithKlein in 2003.^[14] After the acquisition of Cetus, Chiron split its operations among five entities: Cetus Oncology, for cancer drugs; the Biocine Company, for vaccines; Chiron Diagnostics, for blood screening and other diagnostic tests (later sold to Bayer AG for $2.1 billion^[15]); Chiron Intraoptics, for eye surgery, and Chiron Technologies, for research and development.^[5]

Products and other acquisitions

In 1992, the company's first product, Proleukin, was approved in United States for the treatment of metastatic melanoma; previously it was only approved for use with kidney cancer.^[16] This was followed a year later by Betaseron, a beta interferon, the first treatment for relapsing-remitting multiple sclerosis and made by Berlex Laboratories Inc.^[17][18] In 1997 Chiron provided the active ingredient, becaplermin, in Regranex, a topical treatment for diabetic foot ulcers, manufactured by Ortho-McNeil Pharmaceutical Inc.^[19] In 2001, Chiron acquired PathoGenesis for its antibiotic drug Tobi,^[20] the first inhaled antibiotic approved for treating lung infections in cystic fibrosis patients.^[21] Having launched its first vaccine product, Fluad, an adjuvant influenza vaccine, in 1996, the vaccine line was expanded significantly in 1998 with the acquisition of the European vaccine businesses of Behring (Germany) and Sclavo (Italy). This was followed in 2003 by the acquisition of PowderJect, the UK-based vaccines company, making Chiron the second-largest flu vaccines provider and the fifth-largest vaccines business in the world.^[22][23] In 1998, Chiron's nucleic acid testing (NAT) blood-testing business was launched in cooperation with Gen-Probe, followed a year later by the launch of the Procleix system, which detects viral RNA and DNA in donated blood and plasma during the very early stages of infection, when those infectious agents are present but cannot be detected by immunodiagnostic tests. Chiron expanded its cancer drug portfolio in 2002 with the acquisition of Matrix Pharmaceuticals Inc and its product tezacitebine.^[24] Chiron also manufactured the MMR vaccine (measles mumps and rubella) at its Liverpool plant.^[25]

Lawsuits

When in 1991 Cetus was acquired it was subject to a lawsuit by the Eastman Kodak Company over the rights to the polymerase chain reaction product, which was settled in 1993.^[18] In 1998, Chiron filed patent infringement suits in Europe, Japan and the US against Roche over its hepatitis C (HCV) products. Chiron was the first to clone HCV in 1987 after five years of research and had since filed over 100 HCV related patents in over 20 countries.^[26] A settlement was reached where Roche Holding A.G. agreed to buy the global semi-exclusive nucleic acid test (NAT) patents for HCV and HIV from Chiron.^[20] Bayer, the company which bought, Chiron Diagnostics sued Chiron Corporation in 2002 citing that it hid patent and equipment problems from them during purchase negotiations.^[27] The case filed in Delaware alleged breach of warranty, fraud, negligent misrepresentation, violation of the duty of good faith and fair dealing and breach of contract claims in connection with the acquisition.^[28] In 2004, Chiron attracted adverse media coverage after the UK government suspended its license for manufacturing Fluvirin, an influenza vaccine, at its plant in Liverpool, England. This action left the United States government short of the vaccine. It later emerged that the Food and Drug Administration (FDA) may have been aware of the problem nine months earlier, but a miscommunication between the company and the FDA left the problem unsolved until the MHRA (Medicines and Healthcare Products Regulatory Agency), the British equivalent of the FDA stepped in and suspended Chiron's license.^[29] The company undertook a remediation program and succeeded in restoring the manufacturing license from MHRA in 2005. However, the incident resulted in a class action lawsuit for nearly $280m being brought against Chiron and its executive for allegedly, in 2003, overstating its ability to manufacture and ship the vaccine Fluvirin, thus allowing Novartis to buy Chiron shares below market value when the plant temporarily closed down. The amount settled in 2008 was for $30m.^[30]

Bombings

On 27 August 2003 two bombs exploded at Chiron's headquarters in Emeryville, California. A group calling itself Revolutionary Cells e-mailed a statement to reporters taking credit for the bombing. Their action was because of ties Chiron had with the pro vivisection company Huntingdon Life Sciences.^[31]

The end of Chiron

Novartis Corporation was the result of a merger between Sandoz Laboratories and Ciba-Geigy in 1994 and owned slightly less than half of Chiron^[32] as part of a Federal Trade Commission order.^[33] Several of Sandoz’s subsidiaries were sold off for reasons of anti monopoly legislation.^[33] In 2005, Novartis made an offer to buy Chiron. Initially this offer was rebuffed, but after the bid was substantially enhanced, Chiron was sold, and became part of Novartis in April, 2006.^[34]

Products

• Agrippal
• Begrivac
• Fluad
• Fluvirin

See also

• Novartis
• Medicines and Healthcare products Regulatory Agency
• British Medical Association
• Food and Drug Administration

References

1. ^ ^{a b c d e f g} Lawrence M. Fisher (13 October 1986). "Biotechnology Spotlight Now Shines On Chiron". The New York Times. http://www.nytimes.com/1986/10/13/business/biotechnology-spotlight-now-shines-on-chiron.html. 
2. ^ ^{a b} "Chiron-Cetus Management". The New York Times. 26 November 1991. http://www.nytimes.com/1991/11/26/business/company-news-chiron-cetus-management.html. 
3. ^ "Chiron to Get $20 Million". The New York Times. 15 November 1998. http://www.nytimes.com/1988/11/15/business/company-news-chiron-to-get-20-million.html. 
4. ^ "Loss at Chiron Is Attributed to Ciba Alliance". The New York Times. 9 May 1995. http://www.nytimes.com/1995/05/09/business/company-reports-loss-at-chiron-is-attributed-to-ciba-alliance.html. 
5. ^ ^{a b} Lawrence M. Fisher (4 April 1993). "A New Model for Biotechnology". The New York Times. http://www.nytimes.com/1993/04/04/business/a-new-model-for-biotechnology.html. 
6. ^ "Chiron Research Unit". The New York Times. 4 October 1988. http://www.nytimes.com/1988/10/04/business/chiron-research-unit.html. 
7. ^ Lawrence M. Fisher (3 March 1989). "Specialist in Diagnostics Now President of Chiron". The New York Times. http://www.nytimes.com/1989/03/03/business/business-people-specialist-in-diagnostics-now-president-of-chiron.html. 
8. ^ "Chiron-Ortho Pact For Du Pont Unit". The New York Times. 3 January 1990. http://www.nytimes.com/1990/01/03/business/company-news-chiron-ortho-pact-for-du-pont-unit.html. 
9. ^ "Chiron Acquisition". The New York Times. 12 April 1991. http://www.nytimes.com/1991/04/12/business/company-news-chiron-acquisition.html. 
10. ^ Andrew Pollack (23 July 1991). "2 Biotech Pioneers To Merge". The New York Times. http://www.nytimes.com/1991/07/23/business/2-biotech-pioneers-to-merge.html. 
11. ^ Lawrence M. Fisher (17 April 1992). "Price of Failure In Biotechnology". The New York Times. http://www.nytimes.com/1992/04/17/business/market-place-price-of-failure-in-biotechnology.html. 
12. ^ "Chiron's President Quits". The New York Times. 8 December 1992. http://www.nytimes.com/1992/12/08/business/company-news-chiron-s-president-quits.html. 
13. ^ "Chief Executive Named at Chiron". The New York Times. 24 March 1998. http://www.nytimes.com/1998/03/24/business/chief-executive-named-at-chiron.html. 
14. ^ "Chiron Hires GlaxoSmithKline Executive as Chief". The New York Times. 21 March 2003. http://www.nytimes.com/2003/03/21/business/company-news-chiron-hires-glaxosmithkline-executive-as-chief.html. 
15. ^ John Tagliabue (18 September 1998). "Bayer Buying Chiron Unit and Stake in Seed Venture; Agfa Offering Set". The New York Times. http://www.nytimes.com/1998/09/18/business/bayer-buying-chiron-unit-and-stake-in-seed-venture-agfa-offering-set.html. 
16. ^ Lawrence M. Fisher (20 December 1997). "F.D.A. Panel Recommends Approval of a Chiron Drug". The New York Times. http://www.nytimes.com/1997/12/20/business/fda-panel-recommends-approval-of-a-chiron-drug.html. 
17. ^ Milt Freudenheim (24 July 1993). "F.D.A. Approves a Multiple Sclerosis Drug". The New York Times. http://www.nytimes.com/1993/07/24/business/company-news-fda-approves-a-multiple-sclerosis-drug.html. 
18. ^ ^{a b} "Chiron Company Profile". The New York Times. 5 August 1993. http://www.nytimes.com/1993/08/05/business/company-reports-chiron-corp-nms.html. 
19. ^ "FDA Clears REGRANEX -- becaplermin -- Gel 0.01% for Diabetic Foot Ulcers; Chiron to Supply Active Ingredient to Ortho-McNeil.". 17 December 1997. http://www.encyclopedia.com/doc/1G1-20078231.html. 
20. ^ ^{a b} Andrew Pollack (15 August 2000). "Chiron to Acquire PathoGenesis for $700 Million". The New York Times. http://www.nytimes.com/2000/08/15/business/technology-chiron-to-acquire-pathogenesis-for-700-million.html. 
21. ^ "FDA Approves Inhaled Antibiotic for Management of Cystic Fibrosis Patients". FDA. 22 December 1997. http://www.hhs.gov/news/press/1997pres/971222.html. 
22. ^ "Chiron Corporation - history". http://www.chemie.de/lexikon/e/Chiron_Corporation/. 
23. ^ "Chiron Corporation / PowderJect Pharmaceuticals plc". UK Office of Fair Trading. 7 July 2003. http://www.oft.gov.uk/advice_and_resources/resource_base/Mergers_home/mergers_fta/2003/chiron. 
24. ^ "Chiron To Buy Matrix, Maker of Cancer Drug". The New York Times. 8 January 2002. http://www.nytimes.com/2002/01/08/business/company-news-chiron-to-buy-matrix-maker-of-cancer-drug.html. 
25. ^ "Chiron vaccines starts work on new state-of-the art vaccines manufacturing plant". Northwest Regional Development Agency. 27 February 2004. http://www.nwda.co.uk/news--events/press-releases/200401/chiron-vaccines-starts-work-on.aspx. 
26. ^ BW HealthWire (16 April 1998). "Chiron Files Infringement Suit in Japan Against Roche On HCV Patent". The Free Library. http://www.thefreelibrary.com/Chiron+Files+Infringement+Suit+in+Japan+Against+Roche+On+HCV+Patent.-a020497328. 
27. ^ "Bayer Sues Over Medical Acquisition". The New York Times. 2 February 2002. http://www.nytimes.com/2002/02/02/business/international-business-bayer-sues-over-medical-acquisition.html. 
28. ^ "Bayer Corporation v. Chiron Corporation". 8 November 2002. http://www.ded.uscourts.gov/MPT/Opinions/Nov2002/02-080.pdf. 
29. ^ David Brown (18 November 2004). "U.S. Knew Last Year of Flu Vaccine Plant's Woes". The Washington Post. http://www.washingtonpost.com/wp-dyn/articles/A58482-2004Nov17.html. 
30. ^ "Chiron Litigation". 5 October 2008. http://www.chironlitigation.com/pdf/50ProposedNoticeofProposedSettlementdocket155.pdf. 
31. ^ Stacy Finz & Bernadette Tansey (30 August 2003). "Animal rights group tied to bombs". San Francisco Chronicle. http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2003/08/30/CHIRON.TMP. 
32. ^ Lawrence M. Fisher (30 January 1997). "Chiron to Make Room for One More at the Top". The New York Times. http://www.nytimes.com/1997/01/30/business/chiron-to-make-room-for-one-more-at-the-top.html. 
33. ^ ^{a b} Docket C-3725 (24 March 1997). "UNITED STATES OF AMERICA BEFORE FEDERAL TRADE COMMISSION". Federal Trade Commission. http://www.ftc.gov/os/1997/04/c3725cmp.pdf. 
34. ^ "Novartis acquisition of Chiron approved by Chiron shareholders". 19 April 2006. http://cws.huginonline.com/N/134323/PR/200604/1045686_5_2.html. 

External links

• Chiron Corporation
• Novartis