Iohexol

Iohexol

Systematic (IUPAC) name
1-N,3-N-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	B(US)
Legal status	℞ Prescription only
Routes	Intrathecal, intravascular, oral, intracavital
Pharmacokinetic data
Protein binding	Low
Metabolism	Nil
Half-life	Variable
Excretion	Renal, unchanged
Identifiers
CAS number	66108-95-0 Y
ATC code	V08AB02
PubChem	CID 3730
DrugBank	DB01362
ChemSpider	3599 Y
UNII	4419T9MX03 Y
KEGG	D01817 Y
ChEBI	CHEBI:31709 Y
ChEMBL	CHEMBL1200455 N
Chemical data
Formula	C19H26I3N3O9
Mol. mass	821.138 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34) Y Key:NTHXOOBQLCIOLC-UHFFFAOYSA-N Y
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Iohexol is a contrast agent, sold under the trade name Omnipaque. It is available in various concentrations, from 140 to 350 milligrams of iodine per milliliter. Omnipaque 350 is commonly used as a contrast agent during coronary angiography.

The osmolality of iohexol ranges from 322 mOsm/kg—approximately 1.1 times that of blood plasma—to 844 mOsm/kg, almost three times that of blood.^[1] Despite this difference, iohexol is still considered a low-osmolality contrast agent; the osmolality of older agents, such as diatrizoate, may be more than twice as high.^[2]

References

1. ^ GE Healthcare (May 2006). "Omnipaque (Iohexol) injection. Product label". DailyMed. U.S. National Library of Medicine. http://dailymed.nlm.nih.gov/dailymed/fdaDrugXsl.cfm?id=3465&type=display. Retrieved 2007-03-28. 
2. ^ Amersham Health (April 2006). "Hypaque (Diatrizoate Meglumine and Diatrizoate Sodium) injection, solution. Product label". DailyMed. U.S. National Library of Medicine. http://dailymed.nlm.nih.gov/dailymed/fdaDrugXsl.cfm?id=997&type=display. Retrieved 2007-03-29. 

External links

• Omnipaque (Iohexol) injection, solution

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Radiocontrast agents Amides Pharmacology stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Pals Ross Lyon Look at other dictionaries: Iohexol — Strukturformel Gemisch von Diastereomeren und Atropisomeren Allgemeines Freiname …   Deutsch Wikipedia iohexol — A monomeric, nonionic, water soluble, low osmolar radiographic contrast medium for urography or angiography. Used intrathecally and intravascularly. * * * io·hex·ol (i″o hekґsol) [USP] a nonionic, water soluble, low osmolality radiopaque… …   Medical dictionary Radiocontrast agent — Radiocontrast agents are a type of medical contrast medium used to improve the visibility of internal bodily structures in an X ray based imaging techniques such as computed tomography (CT) or radiography (commonly known as X ray imaging).… …   Wikipedia Chronische Niereninsuffizienz der Katze — Die chronische Niereninsuffizienz der Katze (CNI) – auch chronische Nierenerkrankung (CNE) oder chronisches Nierenversagen genannt – ist eine unheilbare, fortschreitende Krankheit, die durch eine allmähliche Abnahme der Funktion… …   Deutsch Wikipedia Radiocontrast — agents (also simply contrast agents or contrast materials) are compounds used to improve the visibility of internal bodily structures in an X ray image.Contrast agents are also used in MRI (Magnetic Resonance Imaging). Although MRI is usually… …   Wikipedia ATC code V08 — A section of the Anatomical Therapeutic Chemical Classification System.V VariousV08A X ray contrast media, iodinatedV08AA Water soluble, nephrotropic, high osmolar X ray contrast media:V08AA01 Diatrizoic acid:V08AA02 Metrizoic acid:V08AA03… …   Wikipedia Diatrizoic acid — IUPAC name 3,5 bis(acetylamino) 2,4,6 triiodobenzoic acid …   Wikipedia Contrast medium — A medical contrast medium (or contrast agent) is a substance used to enhance the contrast of structures or fluids within the body in medical imaging.[1] It is commonly used to enhance the visibility of blood vessels and the gastrointestinal tract …   Wikipedia Contrast-enhanced ultrasound — (CEUS) is the application of ultrasound contrast medium to traditional medical sonography. Ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances. This may be the surface of a… …   Wikipedia Gadopentetic acid — Clinical data AHFS/Drugs.com Consumer Drug …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”