- Iodixanol
drugbox
IUPAC_name = 5 - [acetyl - [3 - [acetyl - [3,5-bis(2,3 - dihydroxypropylcarbamoyl) - 2,4,6 - triiodo - phenyl] amino] - 2 - hydroxy - propyl] amino] - N,N' - bis(2,3 - dihydroxypropyl) - 2,4,6 - triiodo - benzene - 1,3 - dicarboxamide
width = 300px
CAS_number = 92339-11-2
ATC_prefix =
ATC_suffix =
PubChem = 3724
DrugBank =
chemical_formula =
C=35 | H=44 | I=6 | N=6 | O=15
molecular_weight = 1550.191
bioavailability =
protein_bound = Negligible
metabolism = Excreted unchanged
elimination_half-life = 2.1 hours
excretion =Renal
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration =Iodixanol, is a contrast agent, sold under the trade name Visipaque. Visipaque is commonly used as a contrast agent during
coronary angiography , particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. It is an iso-osmolar contrast agent, with anosmolality of 290 mOsm/kg H2O, the same as blood. It is sold in 2 main concentrations 270 mgI/ml and 320 mgI/ml - hence the name Visipaque 270 or 320. It is sold in single dose units and a large 500ml plastic bottle for multi-dose dispensingIt was originally made by Nycomed, which then merged with Amersham which finally was bought by Jeff Immelt to become GE Healthcare. The majority of Visipaque is made in Cork, Ireland, with additional plants in China and Oslo. All Iodixanol bulk powder is made in Norway and shipped to the various plants for final manufacture.
For gradient density centrifugation, the product is known as OptiPrep.
A very similar product also manufactured by GE Healthcare is Omnipaque (
Iohexol as the main drug substance).External links
* [http://www.amershamhealth-us.com/visipaque/ http://www.amershamhealth-us.com/visipaque/]
*
Wikimedia Foundation. 2010.
