Heterosis

Not to be confused with Heterozygosity, or with Heterotic string theory.

See also: Heterozygote advantage

A mixed-breed dog

Heterosis, or hybrid vigor, or outbreeding enhancement, is the improved or increased function of any biological quality in a hybrid offspring. The adjective derived from heterosis is heterotic.

Heterosis is the occurrence of a superior offspring from mixing the genetic contributions of its parents. These effects can be due to Mendelian or non-Mendelian inheritance.

Definitions

In proposing the term heterosis to replace the older term heterozygosis, G.H. Shull aimed to avoid limiting the term to the effects that can be explained by heterozygosity in Mendelian inheritance.^[1]

The physiological vigor of an organism as manifested in its rapidity of growth, its height and general robustness, is positively correlated with the degree of dissimilarity in the gametes by whose union the organism was formed … The more numerous the differences between the uniting gametes — at least within certain limits — the greater on the whole is the amount of stimulation … These differences need not be Mendelian in their inheritance … To avoid the implication that all the genotypic differences which stimulate cell-division, growth and other physiological activities of an organism are Mendelian in their inheritance and also to gain brevity of expression I suggest … that the word 'heterosis' be adopted.

Heterosis is the opposite of inbreeding depression. Inbreeding depression leads to offspring with deleterious traits due to homozygosity. The term heterosis often causes controversy, particularly in selective breeding of domestic animals, because it is sometimes claimed that all crossbred plants and animals are genetically superior to their parents^{[citation needed]}. This is untrue, as only some hybrids are genetically superior. The inverse of heterosis, when a hybrid inherits traits from its parents that are not fully compatible, with deleterious results, is outbreeding depression.

Genetic basis of heterosis

Main article: Dominance versus overdominance

Two competing hypotheses, not necessarily mutually exclusive, have been developed to explain hybrid vigor. The dominance hypothesis attributes the superiority of hybrids to the suppression of undesirable (deleterious) recessive alleles from one parent by dominant alleles from the other. It attributes the poor performance of inbred strains to the loss of genetic diversity, with the strains becoming purely homozygous deleterious alleles at many loci. The overdominance hypothesis states that some combinations of alleles (which can be obtained by crossing two inbred strains) are especially advantageous when paired in a heterozygous individual. The concept of heterozygote advantage/overdominance is not restricted to hybrid lineages. This hypothesis is commonly invoked to explain the persistence of many alleles (most famously the erythrocyte-sickling allele) that are harmful in homozygotes; in normal circumstances, such harmful alleles would be removed from a population through the process of natural selection. Like the dominance hypothesis, it attributes the poor performance of many inbred strains to a high frequency of these harmful recessive alleles and the associated high frequency of homozygous-recessive genotypes.

In plants

Crosses between inbreds from different heterotic groups result in vigorous F1 hybrids with significantly more heterosis than F1 hybrids from inbreds within the same heterotic group or pattern. Heterotic groups are created by plant breeders to classify inbred lines, and can be progressively improved by reciprocal recurrent selection.

Heterosis is used to increase yields, uniformity, and vigor. Hybrid breeding methods are used in maize, sorghum, rice, sugar beet, onion, spinach, sunflowers, and broccoli.

Corn (maize)

Nearly all field corn (maize) grown in most developed nations exhibits heterosis. Modern corn hybrids substantially outyield conventional cultivars and respond better to fertilizer.

Corn heterosis was famously demonstrated in the early 20th century by George H. Shull and Edward M. East after hybrid corn was invented by Dr. William James Beal of Michigan State University based on work begun in 1879 at the urging of Charles Darwin. Dr. Beal's work led to the first published account of a field experiment demonstrating hybrid vigor in corn, by Eugene Davenport and Perry Holden, 1881. These various pioneers of botany and related fields showed that crosses of inbred lines made from a Southern dent and a Northern flint, respectively, showed substantial heterosis and outyielded conventional cultivars of that era. However, at that time such hybrids could not be economically made on a large scale for use by farmers. Donald F. Jones at the Connecticut Agricultural Experiment Station, New Haven invented the first practical method of producing a high-yielding hybrid maize in 1914-1917. Jones' method produced a double-cross hybrid, which requires two crossing steps working from four distinct original inbred lines. Later work by corn breeders produced inbred lines with sufficient vigor for practical production of a commercial hybrid in a single step, the single-cross hybrids. Single-cross hybrids are made from just two original parent inbreds. They are generally more vigorous and also more uniform than the earlier double-cross hybrids. The process of creating these hybrids often involves detasseling.

Temperate maize hybrids are derived from two main heterotic groups: Iowa Stiff Stalk Synthetic, often referred to as BSSS,^{[clarification needed]} and non stiff stalk.^{[citation needed]}

Hybrid livestock

The concept of heterosis is also applied in the production of commercial livestock. In cattle, hybrids between Black Angus and Hereford produce a hybrid known as a "Black Baldy". In swine, "blue butts" are produced by the cross of Hampshire and Yorkshire. Other, more exotic hybrids such as "beefalo" are also used for specialty markets.

Within poultry, sex-linked genes have been used to create hybrids in which males and females can be sorted at one day old by color. Specific genes used for this are genes for barring and wing feather growth. Crosses of this sort create what are sold as Black Sex-links, Red Sex-links, and various other crosses that are known by trade names.

Commercial broilers are produced by crossing different strains of White Rocks and White Cornish, the Cornish providing a large frame and the Rocks providing the fast rate of gain. The hybrid vigor produced allows the production of uniform birds with a marketable carcass at 6–9 weeks of age.

Likewise, hybrids between different strains of White Leghorn are used to produce laying flocks that provide the majority white eggs for sale in the United States.

Humans

Experimental breeding of humans is considered unethical, so any evidence of heterosis in humans is derived from observational studies^[2] It has been suggested that many beneficial effects on average health, intelligence and height have resulted from an increased heterosis, in turn resulting from increased mixing of the human population such as by urbanization.^[3]

See also

• F1 hybrid
• Heterozygote advantage

References

1. ^ George Harrison Shull (1948). "What Is "Heterosis"?". Genetics 33 (5): 439–446. PMC 1209417. PMID 17247290. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1209417. 
2. ^ Penrose, L. S. (1955). "Evidence of heterosis in man". Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 144 (915): 203–213. PMID 13266803.  edit [1]
3. ^ Last paragraphs in Discussion section in: Rudan, I.; Carothers, A. D.; Polasek, O.; Hayward, C.; Vitart, V.; Biloglav, Z.; Kolcic, I.; Zgaga, L. et al. (2008). "Quantifying the increase in average human heterozygosity due to urbanisation". European Journal of Human Genetics 16 (9): 1097–1102. doi:10.1038/ejhg.2008.48. PMID 18322453.  edit [2]

Further reading

• HYBRID VIGOR IN PLANTS AND ITS RELATIONSHIP TO INSECT POLLINATION — a section from Insect Pollination Of Cultivated Crop Plants by S.E. McGregor, USDA
• Hybrids & Heirlooms — an article from University of Illinois Extension
• Mingroni, M.A. (2004). "The secular rise in IQ: Giving heterosis a closer look". Intelligence 32: 65–83. doi:10.1016/S0160-2896(03)00058-8. 
• Nagoshi, C. T. & Johnson, R. C. (1986). "The ubiquity of g". Personality and Individual Differences 7 (2): 201–7. doi:10.1016/0191-8869(86)90056-5. 
• http://www.nwfsc.noaa.gov/publications/techmemos/tm30/lynch.html
• Birchler JA, Auger DL, Riddle NC (October 2003). "In Search of the Molecular Basis of Heterosis". Plant Cell 15 (10): 2236–9. doi:10.1105/tpc.151030. PMC 540269. PMID 14523245. http://www.plantcell.org/cgi/pmidlookup?view=long&pmid=14523245. 
• Roybal, J. (July 1, 1998) “Ranchstar” beefmagazine.com
• Sex-Links
• Winfridus Bakker (2006) “Enhanced Hybrid Vigor Benefits Breeder and Broiler” Cobb Focus Issue 2, 2006.