Diagonal band of Broca

Brain: Diagonal band of Broca
Base of brain. (Diagonal band of Broca not labeled, but anterior perforated substance labeled at center.)
Human brainstem, anterior view. (Diagonal band of Broca not labeled, but anterior perforated substance is #5.)
Latin	stria diagonalis
Gray's	subject #191 868
NeuroNames	hier-267
MeSH	Diagonal+Band+of+Broca

The diagonal band of Broca forms the medial margin of the anterior perforated substance.^[1]

Contents

It consists of fibers that are said to arise in the parolfactory area, the gyrus subcallosus and the anterior perforated substance, and course backward in the longitudinal striae to the dentate gyrus and the hippocampal region.

This is a cholinergic bundle of nerve fibers posterior to the anterior perforated substance. It interconnects the paraterminal gyrus in the septal area with the hippocampus and lateral olfactory area.

Function

Along with the septum pellucidum and medial septal nucleus, the diagonal band of Broca is believed to be involved in the generation of theta waves in the hippocampus.^[2]

Its behavior can be altered by nerve growth factor.^[3]

References

1. ^ Fix, James D. (2002). Neuroanatomy. Hagerstwon, MD: Lippincott Williams & Wilkins. pp. 338. ISBN 0-7817-2829-0. 
2. ^ O'Keefe, John; Andersen, Per; Morris, Richard; David Amaral; Tim Bliss (2007). The hippocampus book. Oxford [Oxfordshire]: Oxford University Press. pp. 480. ISBN 0-19-510027-1. 
3. ^ Huh CY, Danik M, Manseau F, Trudeau LE, Williams S (February 2008). "Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR". J. Neurosci. 28 (6): 1404–9. doi:10.1523/JNEUROSCI.4851-07.2008. PMID 18256260. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=18256260. 

This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained within it may be outdated.