Insulator (genetics)

Insulator (genetics)
For electrical insulator, see Insulator (Electrical).
For other uses, see Insulation (disambiguation).
Gene enhancer.svg

An insulator is a genetic boundary element that plays two distinct roles in gene expression, either as an enhancer-blocking element, or more rarely as a barrier against condensed chromatin proteins spreading onto active chromatin. The need for them arises where two adjacent genes on a chromosome have very different transcription patterns, and it is critical that the inducing or repressing mechanisms of one do not interfere with the neighbouring gene.[1]

References

  1. ^ Burgess-Beusse, B, et al. (December 2002). "The insulation of genes from external enhancers and silencing chromatin". Proc. Natl Acad. Sci. USA 9 (Suppl 4): 16433–16437. doi:10.1073/pnas.162342499. PMC 139905. PMID 12154228. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139905. 
v · Transcription (Prokaryotic, Eukaryotic)
Transcriptional regulation
prokaryotic
eukaryotic
both
Promotion
Initiation (prokaryotic,
eukaryotic)
Transcription start site
Elongation
Termination
(prokaryotic,
eukaryotic)
see also disorders of transcription and post transcriptional modification
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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