EZH2

EZH2

Enhancer of zeste homolog 2 (Drosophila), also known as EZH2, is a human gene.

PBB_Summary
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summary_text = This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: EZH2 enhancer of zeste homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2146| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zeidler M, Kleer CG |title=The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer. |journal=J. Mol. Histol. |volume=37 |issue= 5-7 |pages= 219–23 |year= 2007 |pmid= 16855786 |doi= 10.1007/s10735-006-9042-9
*cite journal | author=De Haan G, Gerrits A |title=Epigenetic control of hematopoietic stem cell aging the case of Ezh2. |journal=Ann. N. Y. Acad. Sci. |volume=1106 |issue= |pages= 233–9 |year= 2007 |pmid= 17332078 |doi= 10.1196/annals.1392.008
*cite journal | author=Hobert O, Jallal B, Ullrich A |title=Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 3066–73 |year= 1996 |pmid= 8649418 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Abel KJ, Brody LC, Valdes JM, "et al." |title=Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. |journal=Genomics |volume=37 |issue= 2 |pages= 161–71 |year= 1997 |pmid= 8921387 |doi= 10.1006/geno.1996.0537
*cite journal | author=Chen H, Rossier C, Antonarakis SE |title=Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. |journal=Genomics |volume=38 |issue= 1 |pages= 30–7 |year= 1997 |pmid= 8954776 |doi= 10.1006/geno.1996.0588
*cite journal | author=Laible G, Wolf A, Dorn R, "et al." |title=Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3219–32 |year= 1997 |pmid= 9214638 |doi= 10.1093/emboj/16.11.3219
*cite journal | author=Cardoso C, Timsit S, Villard L, "et al." |title=Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. |journal=Hum. Mol. Genet. |volume=7 |issue= 4 |pages= 679–84 |year= 1998 |pmid= 9499421 |doi=
*cite journal | author=van Lohuizen M, Tijms M, Voncken JW, "et al." |title=Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3572–9 |year= 1998 |pmid= 9584197 |doi=
*cite journal | author=Sewalt RG, van der Vlag J, Gunster MJ, "et al." |title=Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3586–95 |year= 1998 |pmid= 9584199 |doi=
*cite journal | author=Denisenko O, Shnyreva M, Suzuki H, Bomsztyk K |title=Point mutations in the WD40 domain of Eed block its interaction with Ezh2. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5634–42 |year= 1998 |pmid= 9742080 |doi=
*cite journal | author=van der Vlag J, Otte AP |title=Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. |journal=Nat. Genet. |volume=23 |issue= 4 |pages= 474–8 |year= 1999 |pmid= 10581039 |doi= 10.1038/70602
*cite journal | author=Cardoso C, Mignon C, Hetet G, "et al." |title=The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders. |journal=Eur. J. Hum. Genet. |volume=8 |issue= 3 |pages= 174–80 |year= 2000 |pmid= 10780782 |doi= 10.1038/sj.ejhg.5200439
*cite journal | author=Raaphorst FM, Otte AP, van Kemenade FJ, "et al." |title=Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation. |journal=J. Immunol. |volume=166 |issue= 10 |pages= 5925–34 |year= 2001 |pmid= 11342607 |doi=
*cite journal | author=O'Connell S, Wang L, Robert S, "et al." |title=Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43065–73 |year= 2001 |pmid= 11571280 |doi= 10.1074/jbc.M104294200
*cite journal | author=Varambally S, Dhanasekaran SM, Zhou M, "et al." |title=The polycomb group protein EZH2 is involved in progression of prostate cancer. |journal=Nature |volume=419 |issue= 6907 |pages= 624–9 |year= 2002 |pmid= 12374981 |doi= 10.1038/nature01075
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Kleer CG, Cao Q, Varambally S, "et al." |title=EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 20 |pages= 11606–11 |year= 2003 |pmid= 14500907 |doi= 10.1073/pnas.1933744100

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