SUZ12

Suppressor of zeste 12 homolog (Drosophila), also known as SUZ12, is a human gene.cite web | title = Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23512| accessdate = ]

PBB_Summary
section_title =
summary_text = This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.cite web | title = Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23512| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Koontz JI, Soreng AL, Nucci M, "et al." |title=Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6348–53 |year= 2001 |pmid= 11371647 |doi= 10.1073/pnas.101132598
*cite journal | author=Birve A, Sengupta AK, Beuchle D, "et al." |title=Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. |journal=Development |volume=128 |issue= 17 |pages= 3371–9 |year= 2001 |pmid= 11546753 |doi=
*cite journal | author=Weinmann AS, Bartley SM, Zhang T, "et al." |title=Use of chromatin immunoprecipitation to clone novel E2F target promoters. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6820–32 |year= 2001 |pmid= 11564866 |doi= 10.1128/MCB.21.20.6820-6832.2001
*cite journal | author=Cao R, Wang L, Wang H, "et al." |title=Role of histone H3 lysine 27 methylation in Polycomb-group silencing. |journal=Science |volume=298 |issue= 5595 |pages= 1039–43 |year= 2002 |pmid= 12351676 |doi= 10.1126/science.1076997
*cite journal | author=Kuzmichev A, Nishioka K, Erdjument-Bromage H, "et al." |title=Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. |journal=Genes Dev. |volume=16 |issue= 22 |pages= 2893–905 |year= 2002 |pmid= 12435631 |doi= 10.1101/gad.1035902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Petek E, Jenne DE, Smolle J, "et al." |title=Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations. |journal=J. Med. Genet. |volume=40 |issue= 7 |pages= 520–5 |year= 2003 |pmid= 12843325 |doi=
*cite journal | author=Wang H, An W, Cao R, "et al." |title=mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 475–87 |year= 2003 |pmid= 14536086 |doi=
*cite journal | author=Huang HY, Ladanyi M, Soslow RA |title=Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. |journal=Am. J. Surg. Pathol. |volume=28 |issue= 2 |pages= 224–32 |year= 2004 |pmid= 15043312 |doi=
*cite journal | author=Cao R, Zhang Y |title=SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. |journal=Mol. Cell |volume=15 |issue= 1 |pages= 57–67 |year= 2004 |pmid= 15225548 |doi= 10.1016/j.molcel.2004.06.020
*cite journal | author=Kehrer-Sawatzki H, Kluwe L, Sandig C, "et al." |title=High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene. |journal=Am. J. Hum. Genet. |volume=75 |issue= 3 |pages= 410–23 |year= 2004 |pmid= 15257518 |doi= 10.1086/423624
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Pasini D, Bracken AP, Jensen MR, "et al." |title=Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. |journal=EMBO J. |volume=23 |issue= 20 |pages= 4061–71 |year= 2004 |pmid= 15385962 |doi= 10.1038/sj.emboj.7600402
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Cha TL, Zhou BP, Xia W, "et al." |title=Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. |journal=Science |volume=310 |issue= 5746 |pages= 306–10 |year= 2005 |pmid= 16224021 |doi= 10.1126/science.1118947
*cite journal | author=Lee TI, Jenner RG, Boyer LA, "et al." |title=Control of developmental regulators by Polycomb in human embryonic stem cells. |journal=Cell |volume=125 |issue= 2 |pages= 301–13 |year= 2006 |pmid= 16630818 |doi= 10.1016/j.cell.2006.02.043
*cite journal | author=Furuno K, Masatsugu T, Sonoda M, "et al." |title=Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 3 |pages= 1051–8 |year= 2006 |pmid= 16712789 |doi= 10.1016/j.bbrc.2006.05.014
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Nucci MR, Harburger D, Koontz J, "et al." |title=Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. |journal=Am. J. Surg. Pathol. |volume=31 |issue= 1 |pages= 65–70 |year= 2007 |pmid= 17197920 |doi= 10.1097/01.pas.0000213327.86992.d1

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