WD repeat-containing protein 77

WD repeat-containing protein 77
WD repeat domain 77
Symbols WDR77; MEP-50; MEP50; MGC2722; Nbla10071; RP11-552M11.3; p44; p44/Mep50
External IDs OMIM611734 MGI1917715 HomoloGene11466 GeneCards: WDR77 Gene
RNA expression pattern
PBB GE WDR77 201420 s at tn.png
PBB GE WDR77 201421 s at tn.png
More reference expression data
Species Human Mouse
Entrez 79084 70465
Ensembl ENSG00000116455 ENSMUSG00000000561
UniProt Q9BQA1 Q3V2T0
RefSeq (mRNA) NM_024102 NM_027432.3
RefSeq (protein) NP_077007 NP_081708.1
Location (UCSC) Chr 1:
111.98 – 111.99 Mb
Chr 3:
105.76 – 105.79 Mb
PubMed search [1] [2]

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.[1][2][3]


WD repeat-containing protein 77 has been shown to interact with CTDP1[4] and Protein arginine methyltransferase 5.[1]


  1. ^ a b Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J Biol Chem 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452. 
  2. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  3. ^ "Entrez Gene: WDR77 WD repeat domain 77". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79084. 
  4. ^ Licciardo, Paolo; Amente Stefano, Ruggiero Luca, Monti Maria, Pucci Piero, Lania Luigi, Majello Barbara (Feb. 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. (England) 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149217. 

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