Baculoviral IAP repeat-containing protein 3

Baculoviral IAP repeat-containing 3, also known as BIRC3, is a human gene.

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summary_text = The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified. [cite web | title = Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=330| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bertoni F, Cavalli F, Cotter FE, Zucca E |title=Genetic alterations underlying the pathogenesis of MALT lymphoma. |journal=Hematol. J. |volume=3 |issue= 1 |pages= 10–3 |year= 2003 |pmid= 11960389 |doi= 10.1038/sj/thj/6200146
*cite journal | author=Rothe M, Pan MG, Henzel WJ, "et al." |title=The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. |journal=Cell |volume=83 |issue= 7 |pages= 1243–52 |year= 1996 |pmid= 8548810 |doi=
*cite journal | author=Liston P, Roy N, Tamai K, "et al." |title=Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. |journal=Nature |volume=379 |issue= 6563 |pages= 349–53 |year= 1996 |pmid= 8552191 |doi= 10.1038/379349a0
*cite journal | author=Uren AG, Pakusch M, Hawkins CJ, "et al." |title=Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4974–8 |year= 1996 |pmid= 8643514 |doi=
*cite journal | author=Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG |title=Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization. |journal=Genomics |volume=37 |issue= 3 |pages= 404–6 |year= 1997 |pmid= 8938457 |doi= 10.1006/geno.1996.0579
*cite journal | author=Roy N, Deveraux QL, Takahashi R, "et al." |title=The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. |journal=EMBO J. |volume=16 |issue= 23 |pages= 6914–25 |year= 1998 |pmid= 9384571 |doi= 10.1093/emboj/16.23.6914
*cite journal | author=Deveraux QL, Roy N, Stennicke HR, "et al." |title=IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. |journal=EMBO J. |volume=17 |issue= 8 |pages= 2215–23 |year= 1998 |pmid= 9545235 |doi= 10.1093/emboj/17.8.2215
*cite journal | author=Young SS, Liston P, Xuan JY, "et al." |title=Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2. |journal=Mamm. Genome |volume=10 |issue= 1 |pages= 44–8 |year= 1999 |pmid= 9892732 |doi=
*cite journal | author=Horrevoets AJ, Fontijn RD, van Zonneveld AJ, "et al." |title=Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. |journal=Blood |volume=93 |issue= 10 |pages= 3418–31 |year= 1999 |pmid= 10233894 |doi=
*cite journal | author=Suzuki H, Motegi M, Akagi T, "et al." |title=API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) |journal=Blood |volume=94 |issue= 9 |pages= 3270–1 |year= 1999 |pmid= 10610122 |doi=
*cite journal | author=Huang H, Joazeiro CA, Bonfoco E, "et al." |title=The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 26661–4 |year= 2000 |pmid= 10862606 |doi= 10.1074/jbc.C000199200
*cite journal | author=Verhagen AM, Ekert PG, Pakusch M, "et al." |title=Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. |journal=Cell |volume=102 |issue= 1 |pages= 43–53 |year= 2000 |pmid= 10929712 |doi=
*cite journal | author=Baens M, Steyls A, Dierlamm J, "et al." |title=Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. |journal=Genes Chromosomes Cancer |volume=29 |issue= 4 |pages= 281–91 |year= 2001 |pmid= 11066071 |doi=
*cite journal | author=Werneburg BG, Zoog SJ, Dang TT, "et al." |title=Molecular characterization of CD40 signaling intermediates. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43334–42 |year= 2001 |pmid= 11562359 |doi= 10.1074/jbc.M104994200
*cite journal | author=Suzuki Y, Imai Y, Nakayama H, "et al." |title=A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 613–21 |year= 2001 |pmid= 11583623 |doi=
*cite journal | author=Li X, Yang Y, Ashwell JD |title=TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. |journal=Nature |volume=416 |issue= 6878 |pages= 345–7 |year= 2002 |pmid= 11907583 |doi= 10.1038/416345a
*cite journal | author=Gordon GJ, Appasani K, Parcells JP, "et al." |title=Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma. |journal=Carcinogenesis |volume=23 |issue= 6 |pages= 1017–24 |year= 2002 |pmid= 12082024 |doi=
*cite journal | author=Sharief MK, Noori MA, Zoukos Y |title=Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy. |journal=J. Neuroimmunol. |volume=129 |issue= 1-2 |pages= 224–31 |year= 2002 |pmid= 12161039 |doi=
*cite journal | author=Ekedahl J, Joseph B, Grigoriev MY, "et al." |title=Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells. |journal=Exp. Cell Res. |volume=279 |issue= 2 |pages= 277–90 |year= 2002 |pmid= 12243753 |doi=

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