BIRC7

Baculoviral IAP repeat-containing 7 (livin), also known as BIRC7, is a human gene.cite web | title = Entrez Gene: BIRC7 baculoviral IAP repeat-containing 7 (livin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79444| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.cite web | title = Entrez Gene: BIRC7 baculoviral IAP repeat-containing 7 (livin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79444| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kasof GM, Gomes BC |title=Livin, a novel inhibitor of apoptosis protein family member. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3238–46 |year= 2001 |pmid= 11024045 |doi= 10.1074/jbc.M003670200
*cite journal | author=Vucic D, Stennicke HR, Pisabarro MT, "et al." |title=ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. |journal=Curr. Biol. |volume=10 |issue= 21 |pages= 1359–66 |year= 2001 |pmid= 11084335 |doi=
*cite journal | author=Lin JH, Deng G, Huang Q, Morser J |title=KIAP, a novel member of the inhibitor of apoptosis protein family. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 820–31 |year= 2001 |pmid= 11162435 |doi= 10.1006/bbrc.2000.4027
*cite journal | author=Ashhab Y, Alian A, Polliack A, "et al." |title=Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. |journal=FEBS Lett. |volume=495 |issue= 1-2 |pages= 56–60 |year= 2001 |pmid= 11322947 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Vucic D, Deshayes K, Ackerly H, "et al." |title=SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP). |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12275–9 |year= 2002 |pmid= 11801603 |doi= 10.1074/jbc.M112045200
*cite journal | author=Sanna MG, da Silva Correia J, Ducrey O, "et al." |title=IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1754–66 |year= 2002 |pmid= 11865055 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gazzaniga P, Gradilone A, Giuliani L, "et al." |title=Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer. |journal=Ann. Oncol. |volume=14 |issue= 1 |pages= 85–90 |year= 2003 |pmid= 12488298 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Crnkovic-Mertens I, Hoppe-Seyler F, Butz K |title=Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene. |journal=Oncogene |volume=22 |issue= 51 |pages= 8330–6 |year= 2004 |pmid= 14614456 |doi= 10.1038/sj.onc.1206973
*cite journal | author=Andersen MH, Reker S, Becker JC, thor Straten P |title=The melanoma inhibitor of apoptosis protein: a target for spontaneous cytotoxic T cell responses. |journal=J. Invest. Dermatol. |volume=122 |issue= 2 |pages= 392–9 |year= 2004 |pmid= 15009721 |doi= 10.1046/j.0022-202X.2004.22242.x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Tanabe H, Yagihashi A, Tsuji N, "et al." |title=Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer. |journal=Lung Cancer |volume=46 |issue= 3 |pages= 299–304 |year= 2005 |pmid= 15541814 |doi= 10.1016/j.lungcan.2004.05.002
*cite journal | author=Yagihashi A, Ohmura T, Asanuma K, "et al." |title=Detection of autoantibodies to survivin and livin in sera from patients with breast cancer. |journal=Clin. Chim. Acta |volume=362 |issue= 1-2 |pages= 125–30 |year= 2006 |pmid= 16026775 |doi= 10.1016/j.cccn.2005.06.009
*cite journal | author=Crnković-Mertens I, Semzow J, Hoppe-Seyler F, Butz K |title=Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells. |journal=J. Mol. Med. |volume=84 |issue= 3 |pages= 232–40 |year= 2006 |pmid= 16437214 |doi= 10.1007/s00109-005-0021-5
*cite journal | author=Ma L, Huang Y, Song Z, "et al." |title=Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. |journal=Cell Death Differ. |volume=13 |issue= 12 |pages= 2079–88 |year= 2007 |pmid= 16729033 |doi= 10.1038/sj.cdd.4401959
*cite journal | author=Yan H, Brouha B, Liu T, "et al." |title=Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase. |journal=J. Dermatol. Sci. |volume=43 |issue= 3 |pages= 189–200 |year= 2006 |pmid= 16806840 |doi= 10.1016/j.jdermsci.2006.05.007
*cite journal | author=Wu H, Ma Y, Zhu Y, "et al." |title=Expression of BIRC7 protein and mRNA in non-Hodgkin's lymphoma. |journal=Leuk. Lymphoma |volume=47 |issue= 6 |pages= 1110–6 |year= 2007 |pmid= 16840203 |doi= 10.1080/10428190500472271
*cite journal | author=Crnković-Mertens I, Muley T, Meister M, "et al." |title=The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells. |journal=Lung Cancer |volume=54 |issue= 2 |pages= 135–42 |year= 2007 |pmid= 16965834 |doi= 10.1016/j.lungcan.2006.07.018

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