Triptorelin

Piperazine

Systematic (IUPAC) name
5-oxo-D-prolyl-L-histidyl-Ltryptophyl-L-seryl-Ltyrosyl-3-(1H-indol-2-yl)-L-alanylleucyl-L-arginyl-L-prolylglycinamide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a697045
Pregnancy cat.	D
Legal status	℞-only
Routes	Implant
Pharmacokinetic data
Excretion	Renal
Identifiers
CAS number	57773-63-4 N
ATC code	L02AE04
PubChem	CID 4837
DrugBank	DB00592
ChemSpider	13835459 Y
UNII	9081Y98W2V Y
KEGG	D00807 N
ChEBI	CHEBI:28568 Y
ChEMBL	CHEMBL1201334 N
Chemical data
Formula	C64H82N18O13
Mol. mass	1311.5 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2 Y Key:GLUUGHFHXGJENI-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂), is a gonadotropin-releasing hormone agonist (GnRH agonist) used at the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl® 0.1

During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy. In contrast, gonadotropin-releasing hormone antagonists do not cause a surge, but a sudden reduction of testosterone levels.
Systematic IUPAC Name: [d-Trp6]GnRH

References

• Lahlou N, Carel JC, Chaussain JL, Roger M (July 2000). "Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics". J Pediatr Endocrinol Metab 13 Suppl 1: 723–37. PMID 10969915. 

• Padula AM (August 2005). "GnRH analogues—agonists and antagonists". Anim Reprod Sci 88 (1–2): 115–26. doi:10.1016/j.anireprosci.2005.05.005. PMID 15955640. 

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This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.v · Categories: GnRH agonists Antineoplastic and immunomodulating drug stubs Genito-urinary system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Blue Collar (film) Clan Sutherland Look at other dictionaries: triptorelin — A drug that is used to treat advanced prostate cancer, and is being studied in the treatment of breast cancer. It belongs to the family of hormonal drugs called gonadotropin releasing hormone analogs. Also called Trelstar …   English dictionary of cancer terms triptorelin pamoate — trip·to·rel·in pam·o·ate (trip″tə relґin) a synthetic analogue of gonadorelin that on prolonged administration suppresses gonadotropin release, used as an antineoplastic in the palliative treatment of prostatic carcinoma and also used… …   Medical dictionary Debiopharm — Group™ Type Société Anonyme Industry biopharmaceutical Founded Lausanne, Switzerland (1979) Founder(s) Dr Rolland Yves Mauvernay Headquarters …   Wikipedia Paraphilia — Classification and external resources MeSH D010262 Paraphilia (in Greek para παρά = beside and philia φιλία = friendship, having the meaning of love) is a biomedical term used to describe sexual arousal to objects, situations, or indi …   Wikipedia Prostate cancer — is a disease in which cancer develops in the prostate, a gland in the male reproductive system. It occurs when cells of the prostate mutate and begin to multiply out of control. These cells may spread (metastasize) from the prostate to other… …   Wikipedia ATC code L02 — A section of the Anatomical Therapeutic Chemical Classification System.L Antineoplastic and immunomodulating agentsL02A Hormones and related agentsL02AA Estrogens:L02AA01 Diethylstilbestrol:L02AA02 Polyestradiol phosphate:L02AA03 Ethinylestradiol …   Wikipedia List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia Nafarelin — Systematic (IUPAC) name (2R) N [(2R) 5 carbamimidamido 1 [(2S) 2 [(carbamoylmethyl)carbamoyl]pyrrolidin 1 yl] 1 oxopentan 2 yl] 2 [(2R) 2 [(2R) 2 [(2R) 3 hydroxy 2 [(2S) 2 [(2S) 3 (1H imidazol 4 yl) 2 {[(2R) 5 oxo …   Wikipedia Danazol — Systematic (IUPAC) name (1S,2R,13R,14S,17R,18S) 17 ethynyl 2,18 dimethyl 7 oxa 6 azapentacyclo[11.7.0.02,10.04,8.014,18]icosa 4(8),5,9 trien 17 ol …   Wikipedia Gonadotropin-releasing hormone agonist — A gonadotropin releasing hormone agonist (GnRH agonist) is a synthetic peptide modeled after the hypothalamic neurohormone GnRH that interacts with the gonadotropin releasing hormone receptor to elicit its biologic response, the release of the… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”