NLR family, pyrin domain containing 5
Symbols NLRP5; CLR19.8; MATER; NALP5; PAN11; PYPAF8
External IDs OMIM609658 MGI1345193 HomoloGene65105 GeneCards: NLRP5 Gene
Species Human Mouse
Entrez 126206 23968
Ensembl ENSG00000171487 ENSMUSG00000015721
UniProt P59047 Q9R1M5
RefSeq (mRNA) NM_153447 NM_001039143
RefSeq (protein) NP_703148 NP_035990
Location (UCSC) Chr 19:
56.51 – 56.57 Mb
Chr 7:
24.17 – 24.23 Mb
PubMed search [1] [2]

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.[1][2] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.

In humans, the NLRP5 protein is encoded by the NLRP5 gene.[3][4][5]


  1. ^ Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)". Hum. Reprod. 24 (2): 415–24. doi:10.1093/humrep/den403. PMID 19054779. 
  2. ^ Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells". J. Reprod. Dev. 56 (1): 41–8. PMID 19815987. 
  3. ^ "Entrez Gene: NLR family". 
  4. ^ Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development". Hum. Reprod. 17 (4): 903–11. PMID 11925379. 
  5. ^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 

Further reading

  • Maraldi T, Riccio M, Sena P, et al. (2009). "MATER protein as substrate of PKCepsilon in human cumulus cells.". Mol. Hum. Reprod. 15 (8): 499–506. doi:10.1093/molehr/gap048. PMID 19542546. 
  • Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885. 
  • Alimohammadi M, Björklund P, Hallgren A, et al. (2008). "Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.". N. Engl. J. Med. 358 (10): 1018–28. doi:10.1056/NEJMoa0706487. PMID 18322283. 
  • Sena P, Riccio M, Marzona L, et al. (2009). "Human MATER localization in specific cell domains of oocytes and follicular cells.". Reprod. Biomed. Online 18 (2): 226–34. PMID 19192343.