NLRP4

NLRP4
NLR family, pyrin domain containing 4
Identifiers
Symbols NLRP4; CLR19.5; CT58; FLJ32126; NALP4; PAN2; PYPAF4; RNH2
External IDs OMIM609645 MGI3056600 HomoloGene75315 GeneCards: NLRP4 Gene
Orthologs
Species Human Mouse
Entrez 147945 446099
Ensembl ENSG00000160505 ENSMUSG00000045693
UniProt Q96MN2 n/a
RefSeq (mRNA) NM_134444 NM_001004194.2
RefSeq (protein) NP_604393 NP_001004194.2
Location (UCSC) Chr 19:
56.35 – 56.39 Mb
Chr 7:
24.09 – 24.15 Mb
PubMed search [1] [2]

NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.[1][2][3]

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][3]

References

  1. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  2. ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269. 
  3. ^ a b "Entrez Gene: NLRP4 NLR family, pyrin domain containing 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147945. 

Further reading


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  • NLRP2 — NLR family, pyrin domain containing 2 Identifiers Symbols NLRP2; CLR19.9; FLJ20510; NALP2; NBS1; PAN1; PYPAF2 External IDs …   Wikipedia

  • NLRP7 — NLR family, pyrin domain containing 7 Identifiers Symbols NLRP7; CLR19.4; FLJ94610; HYDM; MGC126470; MGC126471; NALP7; NOD12; PAN7; PYPAF3 External IDs …   Wikipedia

  • NLRP12 — NLR family, pyrin domain containing 12 Identifiers Symbols NLRP12; CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2 External IDs …   Wikipedia

  • NLRP1 — NLR family, pyrin domain containing 1 Обозначения Символы …   Википедия

  • NLRP3 — NLR family, pyrin domain containing 3 Обозначения Символы NLRP3; AGTAVPRL, AII, AVP, FCAS, FCU, NALP3, PYPAF1, MWS, CLR1.1 Entrez Gene …   Википедия

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