NLRP6

NLRP6
NLR family, pyrin domain containing 6
Identifiers
Symbols NLRP6; CLR11.4; NALP6; PAN3; PYPAF5
External IDs OMIM609650 MGI2141990 HomoloGene15881 GeneCards: NLRP6 Gene
Orthologs
Species Human Mouse
Entrez 171389 101613
Ensembl ENSG00000174885 ENSMUSG00000038745
UniProt P59044 Q91WS2
RefSeq (mRNA) NM_138329 NM_001081389.1
RefSeq (protein) NP_612202 NP_001074858.1
Location (UCSC) Chr 11:
0.28 – 0.29 Mb
Chr 7:
148.11 – 148.11 Mb
PubMed search [1] [2]

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.[1]

References

  1. ^ Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1-3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. 

Further reading

  • Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. 
  • Albrecht M, Domingues FS, Schreiber S, Lengauer T (2003). "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles.". FEBS Lett. 538 (1-3): 173–7. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874. 
  • Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation.". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  • Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269. 

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Look at other dictionaries:

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  • NOD1 — Nucleotide binding oligomerization domain containing 1 PDB rendering based on 2b1w …   Wikipedia

  • NLRP1 — NLR family, pyrin domain containing 1 Rendering of NLRP1 from PDB 1PN5 …   Wikipedia

  • NLRC4 — NLR family, CARD domain containing 4 Identifiers Symbols NLRC4; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF External IDs …   Wikipedia

  • NLRP2 — NLR family, pyrin domain containing 2 Identifiers Symbols NLRP2; CLR19.9; FLJ20510; NALP2; NBS1; PAN1; PYPAF2 External IDs …   Wikipedia

  • NLRP7 — NLR family, pyrin domain containing 7 Identifiers Symbols NLRP7; CLR19.4; FLJ94610; HYDM; MGC126470; MGC126471; NALP7; NOD12; PAN7; PYPAF3 External IDs …   Wikipedia

  • NLRP12 — NLR family, pyrin domain containing 12 Identifiers Symbols NLRP12; CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2 External IDs …   Wikipedia

  • NLRP4 — NLR family, pyrin domain containing 4 Identifiers Symbols NLRP4; CLR19.5; CT58; FLJ32126; NALP4; PAN2; PYPAF4; RNH2 External IDs …   Wikipedia

  • NLRP1 — NLR family, pyrin domain containing 1 Обозначения Символы …   Википедия

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