NLRP12

NLRP12
NLR family, pyrin domain containing 12
Identifiers
Symbols NLRP12; CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2
External IDs OMIM609648 HomoloGene16972 GeneCards: NLRP12 Gene
Orthologs
Species Human Mouse
Entrez 91662 378425
Ensembl ENSG00000142405 ENSMUSG00000078817
UniProt P59046 n/a
RefSeq (mRNA) NM_033297.2 NM_001033431.1
RefSeq (protein) NP_150639.1 NP_001028603.1
Location (UCSC) Chr 19:
54.3 – 54.33 Mb
Chr 7:
3.22 – 3.25 Mb
PubMed search [1] [2]

NACHT, LRR and PYD domains-containing protein 12 is a protein that in humans is encoded by the NLRP12 gene.[1][2][3]

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][3]

References

  1. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  2. ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269. 
  3. ^ a b "Entrez Gene: NLRP12 NLR family, pyrin domain containing 12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91662. 

Further reading


Wikimedia Foundation. 2010.

Нужен реферат?

Look at other dictionaries:

  • NLRP12 — Обозначения Символы NLRP12; CLR19.3, Monarch1, PAN6, PYPAF7, RNO2, NALP12 Entrez Gene …   Википедия

  • NOD2 — Nucleotide binding oligomerization domain containing 2 Identifiers Symbols NOD2; ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1 External IDs …   Wikipedia

  • NOD1 — Nucleotide binding oligomerization domain containing 1 PDB rendering based on 2b1w …   Wikipedia

  • NLRP1 — NLR family, pyrin domain containing 1 Rendering of NLRP1 from PDB 1PN5 …   Wikipedia

  • NLRC4 — NLR family, CARD domain containing 4 Identifiers Symbols NLRC4; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF External IDs …   Wikipedia

  • NLRP2 — NLR family, pyrin domain containing 2 Identifiers Symbols NLRP2; CLR19.9; FLJ20510; NALP2; NBS1; PAN1; PYPAF2 External IDs …   Wikipedia

  • NLRP7 — NLR family, pyrin domain containing 7 Identifiers Symbols NLRP7; CLR19.4; FLJ94610; HYDM; MGC126470; MGC126471; NALP7; NOD12; PAN7; PYPAF3 External IDs …   Wikipedia

  • NLRP4 — NLR family, pyrin domain containing 4 Identifiers Symbols NLRP4; CLR19.5; CT58; FLJ32126; NALP4; PAN2; PYPAF4; RNH2 External IDs …   Wikipedia

  • NLRP1 — NLR family, pyrin domain containing 1 Обозначения Символы …   Википедия

  • NLRP3 — NLR family, pyrin domain containing 3 Обозначения Символы NLRP3; AGTAVPRL, AII, AVP, FCAS, FCU, NALP3, PYPAF1, MWS, CLR1.1 Entrez Gene …   Википедия

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”