NLRP14

NLR family, pyrin domain containing 14
Identifiers
Symbols	NLRP14; CLR11.2; GC-LRR; NALP14; NOD5; PAN8
External IDs	OMIM: 609665 MGI: 1924108 HomoloGene: 18531 GeneCards: NLRP14 Gene
Gene Ontology Molecular function • nucleotide binding • ATP binding Biological process • multicellular organismal development • spermatogenesis • cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	338323	76858
Ensembl	ENSG00000158077	ENSMUSG00000016626
UniProt	Q86W24	Q6B966
RefSeq (mRNA)	NM_176822	NM_001002894.2
RefSeq (protein)	NP_789792	NP_001002894.2
Location (UCSC)	Chr 11: 7.04 – 7.09 Mb	Chr 7: 114.31 – 114.34 Mb
PubMed search	[1]	[2]

NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.^[1] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.^[2]

References

1. ^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
2. ^ Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801. 

Further reading

• Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885. 
• Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins LRR proteins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат NLRP13 NLRP5 Look at other dictionaries: NLRP14 — Обозначения Символы NLRP14; NALP14, CLR11.2, GC LRR, Nalp iota, NOD5, PAN8 Entrez Gene …   Википедия NOD-like receptor — The NOD like receptors (NLRs), in short for Nucleotide Oligomerization Domain receptors, are cytoplasmic proteins that may have a variety of functions in regulation of inflammatory and apoptotic responses. NLRs are encoded by genes from a large… …   Wikipedia NOD2 — Nucleotide binding oligomerization domain containing 2 Identifiers Symbols NOD2; ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1 External IDs …   Wikipedia NOD1 — Nucleotide binding oligomerization domain containing 1 PDB rendering based on 2b1w …   Wikipedia NLRP1 — NLR family, pyrin domain containing 1 Rendering of NLRP1 from PDB 1PN5 …   Wikipedia NLRC4 — NLR family, CARD domain containing 4 Identifiers Symbols NLRC4; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF External IDs …   Wikipedia NLRP2 — NLR family, pyrin domain containing 2 Identifiers Symbols NLRP2; CLR19.9; FLJ20510; NALP2; NBS1; PAN1; PYPAF2 External IDs …   Wikipedia NLRP7 — NLR family, pyrin domain containing 7 Identifiers Symbols NLRP7; CLR19.4; FLJ94610; HYDM; MGC126470; MGC126471; NALP7; NOD12; PAN7; PYPAF3 External IDs …   Wikipedia NLRP12 — NLR family, pyrin domain containing 12 Identifiers Symbols NLRP12; CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2 External IDs …   Wikipedia NLRP4 — NLR family, pyrin domain containing 4 Identifiers Symbols NLRP4; CLR19.5; CT58; FLJ32126; NALP4; PAN2; PYPAF4; RNH2 External IDs …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”