NLRC5

NLR family, CARD domain containing 5
Identifiers
Symbols	NLRC5; CLR16.1; FLJ21709; FLJ39711; NOD27; NOD4
External IDs	OMIM: 613537 MGI: 3612191 HomoloGene: 88935 GeneCards: NLRC5 Gene
Gene Ontology Molecular function • nucleotide binding • RNA polymerase II core promoter sequence-specific DNA binding • protein binding • ATP binding Cellular component • nucleus • cytoplasm • cytosol • cytosol Biological process • negative regulation of NF-kappaB transcription factor activity • negative regulation of type I interferon production • regulation of kinase activity • innate immune response • positive regulation of MHC class I biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • defense response to virus • positive regulation of interferon-gamma-mediated signaling pathway • positive regulation of interferon-gamma-mediated signaling pathway • negative regulation of type I interferon-mediated signaling pathway • positive regulation of type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84166	434341
Ensembl	ENSG00000140853	ENSMUSG00000031773
UniProt	Q86WI3	Q3U1H4
RefSeq (mRNA)	NM_032206	NM_001033207
RefSeq (protein)	NP_115582	NP_001028379
Location (UCSC)	Chr 16: 57.02 – 57.12 Mb	Chr 8: 97 – 97.03 Mb
PubMed search	[1]	[2]

NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity.^[1][2][3]

In humans, the NLRC5 protein is encoded by the NLRC5 gene.^[4] It has also been called NOD27, NOD4, and CLR16.1.

References

1. ^ Neerincx A, Lautz K, Menning M, et al. (June 2010). "A role for the human NLR family member NLRC5 in antiviral responses". J Biol Chem 285 (34): 26223–32. doi:10.1074/jbc.M110.109736. PMC 2924034. PMID 20538593. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2924034. 
2. ^ Cui J, Zhu L, Xia X, et al. (April 2010). "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways". Cell 141 (3): 483–96. doi:10.1016/j.cell.2010.03.040. PMID 20434986. 
3. ^ Kuenzel S, Till A, Winkler M, et al. (February 2010). "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses". J. Immunol. 184 (4): 1990–2000. doi:10.4049/jimmunol.0900557. PMID 20061403. 
4. ^ Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Núñez G (March 2003). "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product". Biochem. Biophys. Res. Commun. 302 (3): 575–80. doi:10.1016/S0006-291X(03)00221-3. PMID 12615073.